Histamine bronchoconstriction reduces airway responsiveness in asthmatic subjects.
Histamine bronchoconstriction reduces airway responsiveness in asthmatic subjects.
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组胺支气管收缩可降低哮喘受试者的气道反应性。
DOI：
10.1164/ajrccm/137.6.1323
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
P. O'Byrne
中科院分区：
文献类型：
--
作者：
P. Manning;P. O'Byrne
哮喘受试者反复吸入组胺会出现快速耐受反应，但吸入乙酰胆碱则不会。本研究的目的是确定先前的组胺支气管收缩是否会降低表现出组胺快速耐受性的轻度哮喘受试者对吸入乙酰胆碱的气道反应性。所有受试者均因反复组胺激发而出现组胺快速耐受。当组胺攻击间隔 1 小时时，平均组胺 PC20 从 3.74 增加至 5.92 mg/ml（p 小于 0.005）。先前的乙酰胆碱支气管收缩并没有降低这些受试者随后吸入乙酰胆碱或组胺的气道反应性。然而，吸入组胺确实降低了所有受试者气道对乙酰胆碱的反应性。吸入乙酰胆碱后的平均乙酰胆碱 PC20 为 3.37 mg/ml (%SD 2.17)，吸入组胺后增加至 7.76 mg/ml (%SD 1.80)（p 小于 0.0005）。因此，这项研究表明，先前的组胺（而非乙酰胆碱）支气管收缩可以部分预防由组胺和乙酰胆碱引起的支气管收缩。因此，组胺支气管收缩引起的气道反应性降低是组胺所特有的，而不是支气管收缩本身所致。然而，组胺支气管收缩后气道反应性降低是非特异性的。
Tachyphylaxis occurs to repeated challenges with inhaled histamine but not with inhaled acetylcholine in asthmatic subjects. This study was undertaken to determine whether prior histamine bronchoconstriction reduces airway responsiveness to inhaled acetylcholine in mild asthmatic subjects demonstrating histamine tachyphylaxis. All subjects developed histamine tachyphylaxis with repeated histamine challenge. The mean histamine PC20 increased from 3.74 to 5.92 mg/ml (p less than 0.005) when the histamine challenges were separated by 1 h. Prior acetylcholine bronchoconstriction did not reduce airway responsiveness to subsequent inhalation of either acetylcholine or histamine in these subjects. However, histamine inhalation did reduce airway responsiveness to acetylcholine in all subjects. The mean acetylcholine PC20 following acetylcholine inhalation was 3.37 mg/ml (%SD 2.17) and this increased to 7.76 mg/ml (%SD 1.80) after histamine inhalation (p less than 0.0005). Thus, this study demonstrates that prior histamine, but not acetylcholine, bronchoconstriction can partially protect against bronchoconstriction caused by both histamine and acetylcholine. Therefore, reduced airway responsiveness caused by histamine bronchoconstriction is specific for histamine and is not due to bronchoconstriction per se. However, the reduced airway responsiveness following histamine bronchoconstriction, is nonspecific.
哮喘受试者中前列腺素 F2 α 对化学介质的支气管运动作用的调节。
DOI：
10.1164/arrd.1984.130.4.571
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Fish,JE;Jameson,LS;Albright,A;Norman,PS
通讯作者：
Norman,PS
前列腺素对犬气管平滑肌神经传递的控制。
DOI：
10.1152/jappl.1984.57.1.129
发表时间：
1984
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Walters,EH;O'Byrne,PM;Fabbri,LM;Graf,PD;Holtzman,MJ;Nadel,JA
通讯作者：
Nadel,JA