One Year Follow-up of Functional Recovery in Neovascular AMD During Monthly Anti-VEGF Treatment
One Year Follow-up of Functional Recovery in Neovascular AMD During Monthly Anti-VEGF Treatment
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DOI：
10.1016/j.ajo.2013.05.037
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发表时间：
2013-10-01
影响因子：
4.2
通讯作者：
Schmidt-Erfurth, Ursula
中科院分区：
文献类型：
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作者：
Munk, Marion R.;Kiss, Christopher;Schmidt-Erfurth, Ursula
设计：前瞻性干预性队列研究。方法：对64例新生血管性老年性黄斑变性(AMD)合并黄斑中心凹下病变的新生血管性AMD患者进行治疗，每月进行远视力、阅读敏感度、最大阅读速度和对比敏感度的检查，并用微视野计评估绝对暗点和相对暗点的百分比以及按面积加权的平均中心视网膜敏感度。采用随机斜率和随机截距模型评价患者的阅读敏感度、距离敏感度、阅读速度、对比敏感度、平均中心视网膜敏感度和暗点面积随年龄、病变类型、病变大小和平均中心敏感度的改善情况。结果：最初，抗血管内皮生长因子治疗在所有功能变量中都有快速的短期效果。观察1年以上远视力(P=0.011)、对比敏感度(P
PURPOSE: To identify neurosensory recovery, testing different functional variables during monthly intravitreal standard anti vascular endothelial growth factor (VEGF) therapy in neovascular age-related macular degeneration (AMD).DESIGN: Prospective interventional cohort study.METHODS: Sixty-four treatment-naive neovascular AMD patients with subfoveal lesions were treated and examined monthly for distance visual acuity, reading acuity, maximum reading speed, and contrast sensitivity and with microperimetry evaluating the percentage of absolute and relative scotoma and mean central retinal sensitivity weighted by area. Improvements in reading acuity, distance acuity, reading speed, contrast sensitivity, mean central retinal sensitivity, and scotoma area in dependence of age, lesion type, lesion size, and mean central retinal sensitivity were evaluated by a random-slope and random-intercept model. Recovery pattern of parameters was compared by correlating the individual slopes of each variable.RESULTS: Initially, a rapid short-term effect of anti-VEGF treatment was documented throughout all functional variables. Progressive functional gain over 1 year was observed for distance visual acuity (P = .011), contrast sensitivity (P