A Self-degradable Curcumin Polymer with Anti-cancer Activity.
A Self-degradable Curcumin Polymer with Anti-cancer Activity.
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具有抗癌活性的可自降解姜黄素聚合物。
DOI：
10.1002/app.46867
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发表时间：
2018
影响因子：
3
通讯作者：
Jitianu,Andrei
中科院分区：
文献类型：
--
作者：
O'Connor,NaphtaliA;Einbond,LindaS;Redenti,Stephen;Sauane,Moira;Jitianu,Andrei
姜黄素是一种被广泛研究和利用的天然产品，用于治疗各种疾病，包括作为胃肠辅助剂和抗癌剂。然而，姜黄素的生物利用度很差。规避低生物利用度的策略是与佐剂或合成改性剂一起给药。在此，我们证明了姜黄素通过与N，N ' -二- Boc - L -胱氨酸缩合而融入到自降解聚合物中。该聚合物在对胱氨酸胺进行脱保护后可自降解。热重分析和差示扫描量热法证实了降解。姜黄素在聚合物中保持其抗癌活性，显示出对HT29人结肠癌细胞和DU - 145前列腺癌细胞的活性。与姜黄素相比，自降解聚合物对HT29细胞的活性增强。©2018 Wiley期刊公司j:。变异较大。Sci.2018、135、46867
Curcumin is a widely researched and utilized natural product used for a variety of ailments, including as a gastrointestinal aide and an anticancer agent. Curcumin, however, suffers from poor bioavailability. A strategy to circumvent poor bioavailability is to administer with an adjuvant or by synthetic modification. Herein, we demonstrate the incorporation of curcumin into a self‐degradable polymer by condensation withN,N′‐di‐Boc‐L‐cystine. The polymer is made self‐degradable upon deprotection of the cystine amines. Degradation is confirmed by thermogravimetric analysis and differential scanning calorimetry. Curcumin retains its anti‐cancer activity within the polymer showing activity against HT29 human colon cancer cells and DU‐145 prostate cancer cells. The self‐degrading polymer showed enhanced activity against HT29 cells compared to that of curcumin. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2018,135, 46867
影响因子：
1.8
作者：
RAWAL, VH;CAVA, MP
通讯作者：
CAVA, MP
影响因子：
5.8
作者：
Anand, Preetha;Nair, Hareesh B.;Sung, Bokyung;Kunnumakkara, Ajaikumar B.;Yadav, Vivek R.;Tekmal, Rajeshwar R.;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
15
作者：
DETAR, DF;SILVERST.R
通讯作者：
SILVERST.R