Dietary vitamins, carotenoids and their sources in relation to age-related macular degeneration risk in China: a population-based case-control study
Dietary vitamins, carotenoids and their sources in relation to age-related macular degeneration risk in China: a population-based case-control study
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DOI：
10.1017/s0007114522002161
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发表时间：
2022-07-27
影响因子：
3.6
通讯作者：
Ma，Le
中科院分区：
文献类型：
--
作者：
Jiang，Hong;Wang，Lina;Ma，Le
机制研究表明抗氧化剂对年龄相关性黄斑变性（AMD）有有益作用。本研究旨在探讨中国人膳食维生素和类胡萝卜素摄入类型和来源与AMD风险之间的关系。对260例AMD病例和260例匹配对照进行配对病例-对照研究。参与者接受了饮食信息和潜在混杂因素的访谈，并进行了全面的眼科检查。使用条件logistic模型估计特定维生素和类胡萝卜素及其主要来源的比值比（OR）和95%置信区间（CI）。比较极值四分位数时，叶黄素的or （95% CI）为0.30 (0.10,0.88)，β-隐黄质的or （95% CI）为0.28（0.11,0.74）。其他膳食维生素和类胡萝卜素摄入量的相关性一般较弱且不显著。菠菜和鸡蛋是叶黄素的重要来源，多吃菠菜和鸡蛋可以降低患AMD的几率。菠菜的ORs （95% CI）分别为0.42（0.20,0.88）和0.52 （95% CI: 0.27, 0.98）。鸡蛋和菠菜摄入量最高的参与者患AMD的几率比鸡蛋和菠菜摄入量最低的参与者要低得多（OR: 0.23; 95% CI: 0.08, 0.71）。总之，摄入更多的叶黄素和富含叶黄素的食物与显著降低AMD的几率有关。这些发现为叶黄素和富含叶黄素的食物在预防AMD方面的益处提供了进一步的证据。
Mechanistic studies have suggested that antioxidants have beneficial effects on age-related macular degeneration (AMD). This study aimed to investigate the association between the types and sources of dietary vitamin and carotenoid intakes and AMD risk in China. A matched case–control study of 260 AMD cases and 260 matched controls was performed. The participants were interviewed for dietary information and potential confounders, and comprehensive ophthalmic examinations were performed. Conditional logistic models were used to estimate the odds ratio (OR) and 95 % confidence interval (CI) of specific vitamins and carotenoids and their main sources. When comparing the extreme quartiles, the ORs (95 % CI) were 0·30 (0·10, 0·88) for lutein and 0·28 (0·11, 0·74) for β-cryptoxanthin. The associations for other dietary vitamin and carotenoid intakes were generally weaker and non-significant. Higher intakes of spinach and egg, which are important sources of lutein, were associated with a reduced odds of AMD. ORs (95% CIs) comparing extreme categories were 0·42 (0·20, 0·88) for spinach and 0·52 (95% CI: 0·27, 0·98) for egg. Participants who were in the highest category of both egg intake and spinach intake had a much greater reduced odds of having AMD (OR: 0·23; 95% CI: 0·08, 0·71) than those in the lowest category of egg intake and spinach intake. In conclusion, a higher intake of lutein and lutein-rich foods was associated with a significantly decreased odds of AMD. These findings provide further evidence of the benefits of lutein and lutein-rich foods in the prevention of AMD.