A novel stimulus artifact removal technique for high-rate electrical stimulation
A novel stimulus artifact removal technique for high-rate electrical stimulation
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DOI：
10.1016/j.jneumeth.2008.01.023
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发表时间：
2008-05-30
影响因子：
3
通讯作者：
Fallon, James B.
中科院分区：
文献类型：
--
作者：
Heffer, Leon F.;Fallon, James B.
破坏电生理记录的电刺激伪影往往使随后对潜在神经反应的分析变得困难。在研究对高频率电刺激反应的短潜伏期神经活动时，这一点尤其明显。我们开发并评估了一种用于从电生理记录中去除刺激伪影的离线技术。在细胞外记录豚鼠听神经纤维时，脉冲式电刺激的频率高达5000次/S。通过将每个刺激伪影事件处的样本点替换为从相邻样本点计算的沿直线内插的值来去除刺激伪影。该技术只要求伪影事件是可识别的，并且伪影持续时间保持小于刺激间间隔和动作电位的时间进程。我们已经证明，这种计算效率高的采样和内插技术以最小的动作电位波形失真消除了刺激伪影。我们认为，这项技术可能在一系列电生理记录系统中有潜在的应用。(C)2008爱思唯尔B.V.保留所有权利。
Electrical stimulus artifact corrupting electrophysiological recordings often makes the subsequent analysis of the underlying neural response difficult. This is particularly evident when investigating short-latency neural activity in response to high-rate electrical stimulation. We developed and evaluated an off-line technique for the removal of stimulus artifact from electrophysiological recordings. Pulsatile electrical stimulation was presented at rates of up to 5000 pulses/s during extracellular recordings of guinea pig auditory nerve fibers. Stimulus artifact was removed by replacing the sample points at each stimulus artifact event with values interpolated along a straight line, computed from neighbouring sample points. This technique required only that artifact events be identifiable and that the artifact duration remained less than both the inter-stimulus interval and the time course of the action potential. We have demonstrated that this computationally efficient sample-and-interpolate technique removes the stimulus artifact with minimal distortion of the action potential waveform. We suggest that this technique may have potential applications in a range of electrophysiological recording systems. (C) 2008 Elsevier B.V. All rights reserved.