Multiple cholesterol granulomas of the breast: A case report and review of the literature.
Multiple cholesterol granulomas of the breast: A case report and review of the literature.
复制标题
乳房多发性胆固醇肉芽肿：病例报告及文献综述。
DOI：
10.1097/md.0000000000033084
复制
发表时间：
2023
期刊：
影响因子：
1.6
通讯作者：
Zhigang Chen
中科院分区：
文献类型：
--
作者：
Meng Jin;Qiang Wu;Bingliang Miao;Jing Jin;Chenyi Gao;Xiaoming Xu;Yingbo Luo;Zhigang Chen
理由
摘要乳房胆固醇肉芽肿是一种罕见的疾病，其定义为胆固醇结晶与异物巨细胞的慢性反应性发炎。本病临床上可模仿乳腺癌表现为无痛可触及的硬结节，影像学表现为边界不清的不规则低回声结节。因此，不常见的病变很容易被误诊为乳腺癌。同时，临床医生对它的认识不足，容易忽视。
患者的关注问题
在这份报告中，我们提出了一个罕见的情况下，多发性胆固醇肉芽肿的乳房，这是回顾性分析，并结合所有11个相关的研究，在过去的50年。
干预措施
患者接受了多次乳腺结节影像学检查，并接受了结节局部切除术。
诊断
该患者被证实最终诊断为良性胆固醇肉芽肿，但最初被认为是乳腺癌。
成果
术后患者未诉不适，术后5个月复查超声未见复发。
教训
通过回顾性分析，动态增强磁共振成像和空芯针活检可以协同帮助临床医生将其与其他乳腺疾病区分开来。为了提高对这种罕见疾病的认识，减少相关的误诊，我们总结了胆固醇肉芽肿的特点，并建议适当的新的诊断和治疗方案，胆固醇肉芽肿患者。
RATIONALE
Cholesterol granuloma of the breast is a rare disease defined as chronic reactive inflammation of cholesterol crystals and foreign body giant cells. This disease can mimic breast cancer in the clinic as painless palpable hard nodules, and imaging shows irregular hypoechoic nodules with unclear boundaries. Therefore, the uncommon lesions can be easily misdiagnosed as breast cancer. Meanwhile, it can be easily neglected by clinicians because of poor understanding.
PATIENT CONCERNS
In this report, we present a rare case of multiple cholesterol granulomas of the breast, which was analyzed retrospectively and combined with all 11 relevant available studies in the last 50 years.
INTERVENTIONS
The patient had undergone multiple breast imaging inspections for breast nodules and had the local resection of nodules.
DIAGNOSES
The patient was confirmed to have a final diagnosis of benign cholesterol granulomas but was initially considered as breast cancer.
OUTCOMES
The patient did not complain of discomfort after surgery, and ultrasound reexamination 5 months after surgery showed no recurrence.
LESSONS
By retrospective analysis, dynamic contrast-enhanced magnetic resonance imaging and core needle biopsy can synergistically help clinicians distinguish it from other breast disease. To raise awareness of such a rare disease and reduce related misdiagnoses, we summarize the characteristics of cholesterol granulomas and recommend appropriate novel diagnosis and treatment regimens for patients with cholesterol granulomas.