ACTIVATION OF CELL-SPECIFIC EXPRESSION OF RAT GROWTH-HORMONE AND PROLACTIN GENES BY A COMMON TRANSCRIPTION FACTOR
ACTIVATION OF CELL-SPECIFIC EXPRESSION OF RAT GROWTH-HORMONE AND PROLACTIN GENES BY A COMMON TRANSCRIPTION FACTOR
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DOI：
10.1126/science.2831625
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发表时间：
1988-03-18
期刊：
影响因子：
56.9
通讯作者：
ROSENFELD, MG
中科院分区：
文献类型：
--
作者：
NELSON, C;ALBERT, VR;ROSENFELD, MG
在垂体前叶中，有五种表型不同的细胞类型，包括产生催乳素（乳营养物）或生长激素（生长营养物）的细胞。多种相关的顺式活性元件表现出协同相互作用，似乎是大鼠催乳素和生长激素基因转录激活的关键决定因素。一种常见的组织特异性阳性转录因子，被称为Pit-1，似乎与每个基因中的所有细胞特异性元素结合，并且是激活催乳素和生长激素基因所必需的。这些数据表明，在发育过程中，一个单一的组织特异性因子激活了一组基因，这些基因最终表现出有限的细胞特异性表达并定义细胞表型。
In the anterior pituitary gland, there are five phenotyically distinct cell types, including cells that produce either prolactin (lactotrophs) or growth hormone (somatotrophs). Multiple, related cis-active elements that exhibit synergistic interactions appear to be the critical determinants of the transcriptional activation of the rat prolactin and growth hormone genes. A common positive tissue-specific transcription factor, referred to as Pit-1, appears to bind to all the cell-specific elements in each gene and to be required for the activation of both the prolactin and growth hormone genes. The data suggest, that in the course of development, a single tissue-specific factor activates sets of genes that ultimately exhibit restricted cell-specific expression and define cellular phenotype.