Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism
Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism
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DOI：
10.20892/j.issn.2095-3941.2019.0228
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Liang Wang
中科院分区：
文献类型：
--
作者：
Tong Wang;Zhiyong Wang;Ruifang Niu;Liang Wang
Anxa2 is the most studied member of the calcium-mediated phospholipid-binding protein family annexins and is a biomarker in.cancers. In this review, we listed clinical findings and confirmed the value of Anxa2 in early diagnosis and prognostic prediction.due to its overexpression and adverse effect on the outcome in most tumors. Anxa2 plays a pivotal role in cancer cell proliferation,.migration, invasion, metastasis, and treatment resistance. Improved understanding of its cancer-promoting function might make.it an ideal target for cancer therapy. Here, we systematically summarized the mechanism of Anxa2 in regulating epithelialmesenchymal.transition (EMT), cytoskeleton dynamicity, cell cycle, apoptosis, angiogenesis, and immunology by using various.tumor models. These data emphasize the potential of Anxa2 for targeted intervention in tumors. Altering Anxa2 expression,.neutralizing the cell surface Anxa2, or inhibiting its activation, such as through Tyr23 phosphorylation, could be considered based.on the regulatory mechanism of Anxa2 in tumor progression.
