Cognitive functioning in meningioma patients: a systematic review.
Cognitive functioning in meningioma patients: a systematic review.
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DOI：
10.1007/s11060-016-2115-z
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发表时间：
2016-06
影响因子：
3.9
通讯作者：
Sitskoorn MM
中科院分区：
文献类型：
--
作者：
Meskal I;Gehring K;Rutten GJ;Sitskoorn MM
本系统综述评估了脑膜瘤患者在手术前和/或手术后伴或不伴辅助放疗的认知功能研究的相关发现和方法学方面。检索PubMed和Web of Science电子数据库至2015年12月。从最初确定的1012篇文章中，有11篇符合本综述的纳入标准。发现了多种方法学上的局限性，包括缺乏治疗前评估、使用的神经心理学测试的数量和类型的变化、用于识别认知缺陷患者的规范数据以及认知障碍的各种定义。研究结果表明，大多数脑膜瘤患者在手术前都面临着几个认知领域的认知缺陷。手术后，大多数患者的认知功能似乎有所改善。然而，与健康对照组相比，他们在广泛的认知功能方面仍然存在障碍。并对今后的研究提出了建议。充分的诊断和治疗认知缺陷可能最终改善脑膜瘤患者的预后和生活质量。
This systematic review evaluates relevant findings and methodologic aspects of studies on cognitive functioning in meningioma patients prior to and/or following surgery with or without adjuvant radiotherapy. PubMed and Web of Science electronic databases were searched until December 2015. From 1012 initially identified articles, 11 met the inclusion criteria for this review. Multiple methodological limitations were identified which include the lack of pre-treatment assessments, variations in the number and types of neuropsychological tests used, the normative data used to identify patients with cognitive deficits, and the variety of definitions for cognitive impairment. Study results suggest that most of meningioma patients are faced with cognitive deficits in several cognitive domains prior to surgery. Following surgery, most of these patients seem to improve in cognitive functioning. However, they still have impairments in a wide range of cognitive functions compared to healthy controls. Suggestions are given for future research. Adequate diagnosis and treatment of cognitive deficits may ultimately lead to improved outcome and quality of life in meningioma patients.