Synthesis of trisubstituted imidazoles by palladium-catalyzed cyclization of O-pentafluorobenzoylamidoximes: application to amino acid mimetics with a C-terminal imidazole.
Synthesis of trisubstituted imidazoles by palladium-catalyzed cyclization of O-pentafluorobenzoylamidoximes: application to amino acid mimetics with a C-terminal imidazole.
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DOI：
10.1021/ol047628p
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发表时间：
2005-01
期刊：
影响因子：
5.2
通讯作者：
S. Zaman;Kitamura Mitsuru;A. Abell
中科院分区：
文献类型：
--
作者：
S. Zaman;Kitamura Mitsuru;A. Abell
以催化量的Pd(PPh3)4和三乙胺为原料，以o -五氟苯甲酰胺肟为原料，制备了具有一系列2位取代基的1-苄基-4-甲基咪唑。该序列提供了具有c端咪唑的光学活性氨基酸模拟物。[结构：见正文]
1-Benzyl-4-methylimidazoles with a range of substituents at the 2-position are prepared from O-pentafluorobenzoylamidoximes on treatment with catalytic amounts of Pd(PPh3)4 and triethylamine. The sequence provides access to optically active amino acid mimetics with a C-terminal imidazole. [structure: see text]