A novel stochastic optimization method for handling misalignments of proton and photon doses in combined treatments

A novel stochastic optimization method for handling misalignments of proton and photon doses in combined treatments
复制标题

一种新的随机优化方法,用于处理组合治疗中质子和光子剂量的偏差

DOI:
10.1088/1361-6560/ac858f
复制
发表时间:
2022
影响因子:
3.5
通讯作者:
Unkelbach, Jan
Unkelbach, Jan
中科院分区:
工程技术2区
文献类型:
--
作者:
Fabiano, Silvia;Torelli, Nathan;Papp, Dávid;Unkelbach, Jan

文献摘要

参考文献

相似文献

Objective.组合质子-光子治疗,其中大多数部分与光子一起递送,只有少数与质子一起递送,可以代表最佳地使用有限质子资源的实用方法。已经表明,当处于危险中的器官(OAR)位于肿瘤内或附近时,最佳的多模态治疗使用质子来对靶体积的部分进行低分级,并且使用光子来在剂量限制的健康组织中实现接近均匀的分级,从而利用分级效应。这些计划可能对范围和设置误差敏感,特别是质子和光子剂量之间的不对准。因此,我们开发了一种新的随机优化方法,直接将这些不确定性的生物有效剂量(BED)为基础的质子和光子计划的同时优化。Approach.该方法考虑期望值
Objective. Combined proton–photon treatments, where most fractions are delivered with photons and only a few are delivered with protons, may represent a practical approach to optimally use limited proton resources. It has been shown that, when organs at risk (OARs) are located within or near the tumor, the optimal multi-modality treatment uses protons to hypofractionate parts of the target volume and photons to achieve near-uniform fractionation in dose-limiting healthy tissues, thus exploiting the fractionation effect. These plans may be sensitive to range and setup errors, especially misalignments between proton and photon doses. Thus, we developed a novel stochastic optimization method to directly incorporate these uncertainties into the biologically effective dose (BED)-based simultaneous optimization of proton and photon plans. Approach. The method considers the expected value
DOI: 10.1053/clon.2002.0174
发表时间: 2003-02-01
期刊: CLINICAL ONCOLOGY
影响因子: 3.4
作者:
Goitein, M;Jermann, M
通讯作者: Jermann, M
DOI: 10.1118/1.598932
发表时间: 2000-04-01
期刊: MEDICAL PHYSICS
影响因子: 3.8
作者:
Wu, QW;Mohan, R
通讯作者: Mohan, R
离子治疗 RBE 加权剂量的分析概率模型
DOI: --
发表时间: 2017
影响因子: 3.5
作者:
H. Wieser;Philipp Hennig;N. Wahl;M. Bangert
通讯作者: M. Bangert
DOI: --
发表时间: 2017
影响因子: 5.7
作者:
C. Miguez;E. Jiménez;B. Palma;H. Miras;A. Ureba;R. Arrans;Francisco Carrasco;A. Illescas;A. Leal
通讯作者: A. Leal