A novel stochastic optimization method for handling misalignments of proton and photon doses in combined treatments
A novel stochastic optimization method for handling misalignments of proton and photon doses in combined treatments
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一种新的随机优化方法,用于处理组合治疗中质子和光子剂量的偏差
DOI:
10.1088/1361-6560/ac858f
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发表时间:
2022
影响因子:
3.5
通讯作者:
Unkelbach, Jan
中科院分区:
文献类型:
--
作者:
Fabiano, Silvia;Torelli, Nathan;Papp, Dávid;Unkelbach, Jan
Objective. Combined proton–photon treatments, where most fractions are delivered with photons and only a few are delivered with protons, may represent a practical approach to optimally use limited proton resources. It has been shown that, when organs at risk (OARs) are located within or near the tumor, the optimal multi-modality treatment uses protons to hypofractionate parts of the target volume and photons to achieve near-uniform fractionation in dose-limiting healthy tissues, thus exploiting the fractionation effect. These plans may be sensitive to range and setup errors, especially misalignments between proton and photon doses. Thus, we developed a novel stochastic optimization method to directly incorporate these uncertainties into the biologically effective dose (BED)-based simultaneous optimization of proton and photon plans. Approach. The method considers the expected value
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影响因子:
3.4
作者:
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通讯作者:
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影响因子:
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作者:
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DOI:
10.1016/j.ijrobp.2013.05.002
发表时间:
2013-08-01
影响因子:
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