Generation of polymerosomes from double-emulsions
Generation of polymerosomes from double-emulsions
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DOI：
10.1021/la050797d
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发表时间：
2005-09-27
期刊：
影响因子：
3.9
通讯作者：
Weitz, DA
中科院分区：
文献类型：
--
作者：
Lorenceau, E;Utada, AS;Weitz, DA
已知双嵌段共聚物可以自发地组织成聚合物囊泡。通常，这是通过薄膜再水化或电形成技术来实现的。提出了一种由双乳液生成聚合物囊泡的新方法。通过同心流体流的破碎，我们生成了精确的油中水中水双乳液；疏水流体是含有溶解的二嵌段共聚物的有机溶剂的挥发性混合物。我们收集双乳液并缓慢蒸发有机溶剂，最终使溶解的双嵌段共聚物自组装成囊状结构。对所有三种流体流的独立控制使聚合物囊泡的精确组装成为可能，并在聚合体内提供有效成分的高效封装。我们也使用双乳液与几个内部滴形成新的聚合体结构。
Diblock copolymers are known to spontaneously organize into polymer vesicles. Typically, this is achieved through the techniques of film rehydration or electroformation. We present a new method for generating polymer vesicles from double emulsions. We generate precision water-in-oil-in-water double emulsions from the breakup of concentric fluid streams; the hydrophobic fluid is a volatile mixture of organic solvent that contains dissolved diblock copolymers. We collect the double emulsions and slowly evaporate the organic solvent, which ultimately directs the self-assembly of the dissolved diblock copolymers into vesicular structures. Independent control over all three fluid streams enables precision assembly of polymer vesicles and provides for highly efficient encapsulation of active ingredients within the polymerosomes. We also use double emulsions with several internal drops to form new polymerosome structures.