High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity
High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity
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DOI：
10.1210/jc.2006-1051
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发表时间：
2006-12-01
影响因子：
5.8
通讯作者：
Shirahata, Akira
中科院分区：
文献类型：
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作者：
Araki, Shunsuke;Dobashi, Kazushige;Shirahata, Akira
内容：日本人容易发生肥胖引起的代谢紊乱，这与血清脂肪细胞因子谱有关，即使在儿童中也是如此。目的：本研究的目的是确定高分子量脂联素（H-Adn）是否比总脂联素（T-Adn）更特异地与肥胖儿童的代谢紊乱相关。设计和设置：在一所大学医院的儿科门诊进行了一项病例（n = 59）对照（n = 28）研究。患者：日本肥胖儿童（38名男孩和21名女孩）连续入组。年龄范围为5 - 15岁（10.3 ± 0.3;平均值± SEM）。非肥胖儿童（15名男孩和13名女孩）被指定为年龄匹配的controls.Main结果测量：血清脂联素多聚体复合物进行了测定ELISA试剂盒。结果：肥胖儿童T-Adn（5.1 ± 0.2 vs. 8.8 ± 0.4 μ g/ml）、H-Adn（1.3 ± 0.1 vs. 4.8 ± 0.4 μ g/ml）和中等分子量Adn均显著低于对照组。调整年龄和性别后，T-和H-Adn与胰岛素和评估胰岛素抵抗的稳态模型呈负相关，而H-Adn（但不是T-Adn）与内脏脂肪面积呈负相关，如计算机断层扫描所确定的。结论：H-Adn比T-Adn更能反映儿童肥胖引起的代谢异常。H-Adn与代谢综合征的发展有关，即使在儿童时期也是如此。
Context: Japanese are prone to obesity-induced metabolic derangement, which is linked to serum adipocytokine profile even in children.Objective: The objective of the study was to determine whether high molecular-weight adiponectin (H-Adn) more specifically relates to metabolic derangement in obese children than total adiponectin (T-Adn).Design and Setting: A case (n = 59) control (n = 28) study was performed at the pediatric clinic of a university hospital.Patients: Japanese obese children (38 boys and 21 girls) were consecutively enrolled. The ages ranged from 5 to 15 (10.3 +/- 0.3; mean +/- SEM) yr. Nonobese children (15 boys and 13 girls) were assigned as age-matched controls.Main Outcome Measures: Serum adiponectin multimeric complexes were assayed by an ELISA kit. The relationship of adiponectin to metabolic abnormalities was evaluated.Results: T-Adn (5.1 +/- 0.2 vs. 8.8 +/- 0.4 mu g/ml), H-Adn (1.3 +/- 0.1 vs. 4.8 +/- 0.4 mu g/ml), and medium molecular weight-Adn were significantly lower in obese than in control children. After adjustment for age and sex, both T- and H-Adn were inversely correlated with insulin and homeostasis model of assessment-insulin resistance, whereas H-Adn (but not T-Adn) inversely correlated with visceral fat area, as determined by computed tomography. Seven obese children were estimated to have metabolic syndrome and showed selective decrease in H-Adn and H/T-Adn.Conclusion: H-Adn reflects metabolic abnormalities due to obesity better than T-Adn in children. H-Adn is associated with the development of metabolic syndrome, even in childhood.