Ruxolitinib: a steroid sparing agent in chronic graft-versus-host disease.
Ruxolitinib: a steroid sparing agent in chronic graft-versus-host disease.
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DOI：
10.1038/s41409-017-0081-5
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发表时间：
2018-07
影响因子：
4.8
通讯作者：
DiPersio JF
中科院分区：
文献类型：
--
作者：
Khoury HJ;Langston AA;Kota VK;Wilkinson JA;Pusic I;Jillella A;Bauer S;Kim AS;Roberts D;Al-Kadhimi Z;Bodo I;Winton E;Arellano M;DiPersio JF
Inhibition of the Janus-associated kinases (JAK) with ruxolitinib (RUX) reduces graft-versus-host disease (GVHD) in preclinical and clinical models. Nineteen allograft recipients with moderate/severe steroid-dependent chronic GVHD received RUX as ≥ 2nd line salvage. RUX was well tolerated, and led to complete/partial resolution of oral (92/7%), cutaneous (82/0%), hepatic (71/28%), gastro-intestinal (75/17%), musculoskeletal (33/67%), pulmonary (0/80%), scleroderma (0/75%), vaginal (0/75%), and ocular (0/100%) chronic GVHD. Overall 18 achieved partial response and 1 complete response according to NIH Consensus Criteria. Responses occurred early and were sustained which enabled discontinuation (68%) or reduction of steroids to physiologic doses (21%). We conclude that RUX is an effective steroid-sparing agent in chronic GVHD.
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影响因子：
4.3
作者：
Wolff, Daniel;Schleuning, Michael;Holler, Ernst
通讯作者：
Holler, Ernst
影响因子：
11.4
作者：
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通讯作者：
von Bubnoff N
DOI：
10.1016/j.bbmt.2015.02.025
发表时间：
2015-06
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
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通讯作者：
Pavletic S
影响因子：
3.7
作者：
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通讯作者：
DiPersio JF
DOI：
10.1016/j.bbmt.2014.12.001
发表时间：
2015-03
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
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通讯作者：
Flowers ME