Consequences of Early Experiences and Exposure to Oxytocin and Vasopressin Are Sexually Dimorphic
Consequences of Early Experiences and Exposure to Oxytocin and Vasopressin Are Sexually Dimorphic
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DOI：
10.1159/000216544
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Bales, Karen L.
中科院分区：
文献类型：
--
作者：
Carter, C. Sue;Boone, Ericka M.;Bales, Karen L.
在社会性一夫一妻制的草原田鼠中，我们观察到早期处理的微小变化以及早期的荷尔蒙控制可以对行为产生长期的和性别二态的影响。这些变化可能部分是通过父母与幼虫相互作用的变化来调节的，作用于依赖催产素(OT)和精氨酸加压素(AVP)的系统。了解内源性和外源性对依赖OT和AVP的系统的影响可能有助于理解性二形态发育障碍，如自闭症，其特征是焦虑增加和社交行为缺陷。版权所有(C)2009 S.Karger AG，巴塞尔
In the socially monogamous prairie vole, we have observed that small changes in early handling, as well as early hormonal manipulations can have long-lasting and sexually dimorphic effects on behavior. These changes may be mediated in part by changes in parental interactions with their young, acting on systems that rely on oxytocin (OT) and arginine vasopressin (AVP). Knowledge of both endogenous and exogenous influences on systems that rely on OT and AVP may be helpful in understanding sexually dimorphic developmental disorders, such as autism, that are characterized by increased anxiety and deficits in social behavior. Copyright (C) 2009 S. Karger AG, Basel