PLASMA AND URINE CARNITINE IN DIABETIC KETOSIS
PLASMA AND URINE CARNITINE IN DIABETIC KETOSIS
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DOI：
10.2337/diab.28.12.1083
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发表时间：
1979-01-01
期刊：
影响因子：
7.7
通讯作者：
HOPPEL, CL
中科院分区：
文献类型：
--
作者：
GENUTH, SM;HOPPEL, CL
肉毒碱是脂肪酸氧化的一个重要因素，因此，在酮酸生产。在血浆中，因此，游离肉毒碱，短链酰基肉毒碱，长链酰基肉毒碱，和总肉毒碱（所有3个馏分的总和）在正常受试者，在糖尿病酮症和糖尿病酮症酸中毒。短链酰基肉毒碱（平均值±. SEM [平均值的标准误差]）在酮症酸中毒性糖尿病患者中显著更高（31.0 . ±. 4.0μ M）和酮性糖尿病患者（11.8 . ±. 1.2μ M）比正常人（5.8 ± 0.5 μ M）高。长链酰基肉毒碱在酮症酸中毒糖尿病患者中显著较高（8.0 ± 0.65）。1.0μ M）比酮症糖尿病患者（20.5 ± 0.5 μ M）高。3.3μ M）比酮性糖尿病患者（31.8 ± 0.5 μ M）高。2.2μ M）或正常（36.5 ± 0.5 μ M）。1.5μ M）。血浆短链酰基肉毒碱与血液β羟丁酸在正常人中升高（r [相关系数] = 0.69，P < 0.001），但在两个糖尿病组中均未升高。糖尿病患者血浆中游离肉毒碱和酰基肉毒碱的异常分布迅速恢复正常，与血液β羟基丁酸，通过胰岛素治疗。后者也导致24小时尿中酰基肉毒碱排泄量减少70%。这些数据与肉毒碱在人糖尿病生酮中的假定作用一致。
Carnitine is an essential factor in fatty acid oxidation and, hence, in ketoacid production. In plasma, therefore, free carnitine, short-chain acylcarnitine, long-chain acylcarnitine, and total carnitine (sum of all 3 fractions) were determined in normal subjects, in diabetics with ketosis and in diabetics in ketoacidosis. Short-chain acylcarnitine (mean .+-. SEM [standard error of the mean]) was significantly higher in ketoacidotic diabetics (31.0 .+-. 4.0 .mu.M) and ketotic diabetics (11.8 .+-. 1.2 .mu.M) than in normals (5.8 .+-. 0.65); long-chain acylcarnitine was significantly higher in ketoacidotic diabetics (8.0 .+-. 1.0 .mu.M) than in ketotic diabetics (20.5 .+-. 3.3 .mu.M) than in ketotic diabetics (31.8 .+-. 2.2 .mu.M) or normals (36.5 .+-. 1.5 .mu.M). Plasma short-chain acylcarnitine correlated positively with blood .beta. hydroxybutyrate in normals (r [correlation coefficient] = 0.69, P < 0.001) but not in either diabetic group. The abnormal distribution in plasma of free carnitine and acylcarnitines in the diabetics was promptly returned toward normal, in parallel with blood .beta. hydroxybutyrate, by insulin treatment. The latter also resulted in a 70% reduction in 24 h urinary excretion of acylcarnitine. These data are consistent with a postulated role for carnitine in diabetic ketogenesis in man.