Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity
Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity
复制标题
DOI：
10.1016/s0378-8741(02)00329-x
复制
发表时间：
2003-02-01
影响因子：
5.4
通讯作者：
Basic, I
中科院分区：
文献类型：
--
作者：
Orsolic, N;Basic, I
本文研究了一种水溶性的抗癌衍生物（WSDP）的抗肿瘤转移作用。肿瘤为CBA小鼠可移植性乳腺癌。通过2 × 105个活肿瘤细胞静脉内产生肺转移。在肿瘤细胞接种之前或之后以50或150 mg/kg的剂量腹膜内给予WSDP。治疗减少了肺转移瘤的数量，WSDP显著抑制了肿瘤生长。WSDP的抗转移活性可能主要由免疫调节活性介导。几个免疫学参数的变化，如生产的淋巴细胞活化因子的腹腔巨噬细胞和这些巨噬细胞在体外杀死肿瘤细胞的效力，淋巴细胞对有丝分裂原的反应，以及重量和脾细胞，分别与WSDP的抗转移性能。基于这些结果，我们推测，抗转移活性包括显著的免疫调节活性，主要是通过巨噬细胞活化增强小鼠的非特异性抗肿瘤抗性。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The antimetastatic efficacy of a water-soluble derivative of propolis (WSDP) was studied. Tumor was a transplantable mammary carcinoma of CBA mouse. Metastases in the lung were generated by 2 x 105 viable tumor cells i.v. WSDP was given intraperitoneally at doses of 50 or 150 mg/kg before or after tumor cell inoculation. Therapies reduced the number of metastases in the lung and tumor growth was suppressed significantly by WSDP. It is likely that antimetastatic activity of the WSDP is mainly mediated by immunomodulatory activity. Changes in several immunological parameters such as production of lymphocyte activating factor by peritoneal macrophages and the efficacy of those macrophages to kill tumor cell in vitro, responses of lymphocytes to mitogen, and weight and cellularity of spleen, respectively, correlated well with antimetastatic properties of the WSDP. Based on results we postulate that the antimetastatic activity of propolis includes a pronounced immunomodulatory activity mainly toward augmentation of nonspecific antitumor resistance in mice via macrophage activation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.