Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages?
Can the sheep model fully represent the human model for the functional evaluation of cervical interbody fusion cages?
复制标题
绵羊模型能否完全代表人体模型进行颈椎椎间融合器的功能评估？
DOI：
10.1007/s10237-018-1104-x
复制
发表时间：
2019-06-01
影响因子：
3.5
通讯作者：
Li, Dichen
中科院分区：
文献类型：
--
作者：
Wang, Ling;Wang, Yingying;Li, Dichen
绵羊模型是动物研究的最有利选择，用于在临床应用之前对宫颈融合假体进行功能评估。但是，绵羊和人之间的显着差异在形态特征和日常活动运动方面存在。应该提出问题，因为两个物种之间的差异是否对绵羊模型的可靠性有影响。构建了宫颈脊柱系统的有限元模型（FEM），以表征两种物种在运动范围（ROM）和生物力学行为方面之间的差异，并且对这两个物种进行了实验性尸体测试，以进行验证。结果表明，绵羊模型代表了人类模型的最坏情况，其应力（多达3倍）和ROM（多达10倍）。此外，绵羊模型对假体设计的变化非常敏感，而人类模型则没有，这表示绵羊模型为其生物力学性能提供了某种设计的相当放大的效果。因此，当将绵羊模型用作各种设计的功能评估的动物模型时，需要谨慎行事，并且本研究中建造的FEM可以用作颈椎笼假体性能评估的有效方法。
Sheep model is the most favourable choice for animal study for functional evaluation of the cervical fusion prostheses before clinical application; however, significantly large differences between sheep and human existed in terms of morphological characteristics and daily-activity motions. Questions should be raised as whether the differences between the two species have influence on the reliability of sheep model. Finite element models (FEM) of the cervical spinal system were built to characterize the differences between the two species with respect to the range of motion (ROM) and biomechanical behaviour, and experimental cadaver tests on both species were employed for validation purposes. Results indicate that sheep model represents the worst-case scenario of the human model with exaggerated stresses (up to 3 times more) and ROM (up to 10 times more). Moreover, sheep model is very sensitive to the variation of prostheses design, whilst human model does not, which denotes that the sheep model provides a rather amplified effect of a certain design for its biomechanical performance. Therefore, caution needs to be taken when sheep models were used as the animal model for functional evaluation over various design, and the FEM built in this study can be employed as an effective methodology for performance evaluation of cage prostheses of cervical spine.