HYPERTENSION, PREGNANCY, AND RISK OF BREAST-CANCER
HYPERTENSION, PREGNANCY, AND RISK OF BREAST-CANCER
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DOI：
10.1093/jnci/81.20.1571
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发表时间：
1989-10-18
影响因子：
10.3
通讯作者：
JANERICH, DT
中科院分区：
文献类型：
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作者：
THOMPSON, WD;JACOBSON, HI;JANERICH, DT
我们利用一项针对 55 岁以下女性的大型病例对照研究的数据，调查了高血压与乳腺癌之间的关系。在未生育的女性中，几乎没有证据表明高血压与乳腺癌之间存在关联。在经产妇女中，如果在最近一次妊娠结束前的任何时间诊断出高血压，则可降低患乳腺癌的风险（比值比 = 0.73；95% 置信区间 = 0.59 - 0.92）。一些早期的研究表明，妊娠期高血压与母体血清甲胎蛋白水平升高之间存在关联。因此，我们的结果与以下假设一致：母亲在怀孕期间接触甲胎蛋白可以保护女性免于随后发生乳腺癌。
We investigated the relationship between hypertension and breast cancer using data from a large case-control study of women younger than 55 years. Among nulliparous women, there was little evidence of an association between hypertension and breast cancer. Among parous women, hypertension reduced the risk of breast cancer if it had been diagnosed at any time in their lives before the end of the most recent pregnancy (odds ratio = 0.73; 95% confidence interval = 0.59 - 0.92). Several earlier studies indicate that there is an association between hypertension during pregnancy and elevated levels of maternal serum .alpha.-fetoprotein. Thus, our results are consistent with the hypothesis that maternal exposure to .alpha.-fetoprotein during pregnancy protects women against the subsequent occurrence of breast cancer.