[Serial diffusion-weighted MRI (DWI) in a patient with sporadic Creuztfeldt-Jakob disease].
[Serial diffusion-weighted MRI (DWI) in a patient with sporadic Creuztfeldt-Jakob disease].
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[散发性克雅氏病患者的系列弥散加权 MRI (DWI)]。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
M. Tsujihata
中科院分区：
文献类型：
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作者：
I. Tomita;Katsuya Sato;Susumu Shirabe;K. Nagasato;A. Satoh;M. Tsujihata
我们对一位CJD患者进行了一系列的弥散加权成像检查，该患者的症状急转直下，进展迅速。DWI显示，在症状出现20天后，额叶和顶叶内皮质区域以及尾状核和壳核的信号增强。T2加权像仅显示尾状核和壳核信号异常，大脑皮层未见异常信号。发病15天后脑脊液中总tau蛋白明显升高，14-3-3蛋白呈阳性。这些蛋白的检测对CJD的诊断具有高度的特异性和敏感性，但目前还不能作为一种快速的常规检测方法。弥散加权成像对CJD的早期诊断无特异性，但有一定的实用价值。
Serial DWIs were performed in a patient with CJD who developed symptoms acutely and progressed rapidly. DWI discloed an increased signal in the frontal and parietal inner cortical areas, and in the caudate nuclei and putamina 20 days after the onset of symptoms. T2-weighted images showed only signal abnormality in the caudate nuclei and putamina, but not in the cerebral cortex. In the CSF obtained 15 days after the onset of symptoms, total tau protein was markedly elevated and 14-3-3 protein was positive. Measurement of these proteins are highly specific and sensitive for the diagnosis of CJD, but not available as a rapid routine examination at present. DWI is not specific, but useful for making the diagnosis of CJD in the early stage of the disease.