Strontium enhances osseointegration of calcium phosphate cement: a histomorphometric pilot study in ovariectomized rats.
Strontium enhances osseointegration of calcium phosphate cement: a histomorphometric pilot study in ovariectomized rats.
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DOI：
10.1186/1749-799x-8-16
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发表时间：
2013-06-07
影响因子：
2.6
通讯作者：
Kasperk C
中科院分区：
文献类型：
--
作者：
Baier M;Staudt P;Klein R;Sommer U;Wenz R;Grafe I;Meeder PJ;Nawroth PP;Kasperk C
磷酸钙骨水泥经常用于骨科和牙科手术。含锶药物在各种临床环境中用作全身成骨细胞活化药物，促进骨化骨的机械稳定性。在标准骨质疏松动物模型中，比较了含锶磷酸钙骨水泥（SPC）和磷酸钙骨水泥（CPC）对骨组织的局部和全身影响。在60只切除卵巢的Sprague-Dawley大鼠的股骨远端干骺端中创建骨缺损。分别用CPC和SPC填充缺损，每组30只。通过植入部位的组织形态计量学评估局部效应。通过测量对侧股骨和脊柱的骨矿物质密度（BMD）评估全身效应。与CPC植入部位相比，SPC的骨整合更快，新骨形成更多。SPC种植体比CPC种植体表现出更多的裂缝，允许种植体内形成更多的骨。两组间股骨骨密度和脊柱骨密度无显著差异。在磷酸钙中加入锶可以刺激植入物内部和周围的骨形成。SPC植入物的锶全身释放不会导致足够高的血清锶水平，从而对该大鼠模型的骨量产生显著的全身效应。
Calcium phosphate cements are used frequently in orthopedic and dental surgeries. Strontium-containing drugs serve as systemic osteoblast-activating medication in various clinical settings promoting mechanical stability of the osteoporotic bone. Strontium-containing calcium phosphate cement (SPC) and calcium phosphate cement (CPC) were compared regarding their local and systemic effects on bone tissue in a standard animal model for osteoporotic bone. A bone defect was created in the distal femoral metaphysis of 60 ovariectomized Sprague-Dawley rats. CPC and SPC were used to fill the defects in 30 rats in each group. Local effects were assessed by histomorphometry at the implant site. Systemic effects were assessed by bone mineral density (BMD) measurements at the contralateral femur and the spine. Faster osseointegration and more new bone formation were found for SPC as compared to CPC implant sites. SPC implants exhibited more cracks than CPC implants, allowing more bone formation within the implant. Contralateral femur BMD and spine BMD did not differ significantly between the groups. The addition of strontium to calcium phosphate stimulates bone formation in and around the implant. Systemic release of strontium from the SPC implants did not lead to sufficiently high serum strontium levels to induce significant systemic effects on bone mass in this rat model.