Power and Wavelength Dependence of Photoenhancement in (CdSe)ZnS-Dopamine in Aqueous Solution and Live Cells
Power and Wavelength Dependence of Photoenhancement in (CdSe)ZnS-Dopamine in Aqueous Solution and Live Cells
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DOI：
10.1524/zpch.2008.6012
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发表时间：
2008-05
期刊：
影响因子：
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通讯作者：
S. Clarke;S. Koshy;J. Zhang;Netta Cohen;J. Nadeau
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文献类型：
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作者：
S. Clarke;S. Koshy;J. Zhang;Netta Cohen;J. Nadeau
当暴露于紫外线或蓝光照射时，与电子供体多巴胺缀合的CdSe（ZnS）量子点在数秒至数分钟的时间过程中显示出光致发光的增强。当点在水溶液中时以及在活细胞的内吞作用之后观察到这种现象。增强的速率与每个量子点的多巴胺缀合物的数量直接相关，并且可以在宽范围内半定量地调节。细胞对颗粒的摄取也取决于表面覆盖度，适度的覆盖度对于摄取和相对信号增强都是理想的。增强是强烈的功率依赖性，也可能显示依赖于波长;然而，直接激发的多巴胺分子是不必要的增强效果。
CdSe(ZnS) quantum dots conjugated to the electron donor dopamine show enhancement of photoluminescence over a time course of seconds to minutes when exposed to ultraviolet or blue irradiation. This phenomenon is observed when the dots are in aqueous solution as well as after endocytosis by living cells. The rate of enhancement is directly related to the number of dopamine conjugates per quantum dot, and can be semi-quantitatively adjusted over a wide range. Uptake of the particles by cells is also dependent upon surface coverage, with moderate coverages proving ideal for both uptake and relative signal enhancement. The enhancement is strongly power-dependent and may also show dependence upon wavelength; however, direct excitation of the dopamine molecule is not necessary for the enhancement effect.