Remodeling capacity of calcified fibrocartilage of the hip
Remodeling capacity of calcified fibrocartilage of the hip
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DOI：
10.1002/ar.a.20066
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发表时间：
2004-08-01
期刊：
影响因子：
--
通讯作者：
Kopp, DV
中科院分区：
文献类型：
--
作者：
Bloebaum, RD;Kopp, DV
众所周知，髋部骨折的发病率随着年龄的增长呈指数级增加，髋部骨折可能是老年人发病率和死亡率的主要原因;这促使了对髋部骨折的大量研究。大多数关于髋部骨折的研究都集中在股骨近端随年龄的形态学变化上。最近在股骨近端钙化纤维软骨已被证明增加分数面积随着年龄的增长，并最终可以弥补高达60%的分数面积的皮质。然而，组织重塑和愈合的能力目前尚不清楚。本研究的目的是确定股骨近端钙化纤维软骨与底层皮质骨相比的重塑能力。用四环素标记法研究了成年雌性绵羊钙化纤维软骨和皮质骨的改建能力。定量每种组织类型内的双标记和单标记的数量，并用配对t检验进行分析。数据显示，与皮质骨相比，钙化纤维软骨中的标记非常少。这表明钙化的纤维软骨缺乏以类似于骨的方式重塑的能力。本研究的结果表明，虽然底层皮质骨正在积极重塑，但钙化的纤维软骨似乎没有类似于皮质骨的重塑能力。(C)2004 Wiley-Liss，Inc.
It is well known that the incidence of hip fractures increases exponentially with age and that hip fractures can be a major cause of morbidity and morality among elderly humans; this has prompted substantial research on hip fractures. The majority of research on hip fractures has focused on morphological changes of the proximal femur with age. Recently calcified fibrocartilage in the proximal femur has been shown to increase in fractional area with age and can ultimately make up to 60% of the fractional area of the cortex. However, the capacity of the tissue to remodel and heal is currently unknown. The purpose of the present study was to determine the remodeling capacity of calcified fibrocartilage on the proximal femur compared to the underlying cortical bone. The remodeling capacity of calcified fibrocartilage and cortical bone was assessed in adult female sheep by means of tetracycline labeling. The number of double and single labels within each tissue type was quantified and analyzed with a paired t-test. The data showed very few labels in the calcified fibrocartilage compared to the cortical bone. This indicated that calcified fibrocartilage lacked a capacity to remodel in a manner similar to bone. The results of this investigation demonstrate that while the underlying cortical bone was actively remodeling, the calcified fibrocartilage appeared to have no remodeling capacity similar to that of cortical bone. (C) 2004 Wiley-Liss, Inc.