Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1
Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1
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DOI：
10.1038/nn.3175
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发表时间：
2012-09-01
影响因子：
25
通讯作者：
Goepfert, Martin C.
中科院分区：
文献类型：
--
作者：
Effertz, Thomas;Nadrowski, Bjoern;Goepfert, Martin C.
难以捉摸的听觉传导通道是通过门控弹簧的拉力直接机械选通的。我们发现，瞬时受体电位(Trp)通道TRPN1(NOMPC)对于果蝇听觉传导通道的这种直接门控是必不可少的，如果TRPN1丢失，通道-弹簧复合体就会被破坏。我们的结果确定TRPN1是苍蝇听觉传导复合体的一个机械成分，可能作为通道和/或门控弹簧。
The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring.