Fabrication of thermoset polyester microfluidic devices and embossing masters using rapid prototyped polydimethylsiloxane molds
Fabrication of thermoset polyester microfluidic devices and embossing masters using rapid prototyped polydimethylsiloxane molds
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DOI：
10.1039/b305074m
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发表时间：
2003-01-01
期刊：
影响因子：
6.1
通讯作者：
Chiu, DT
中科院分区：
文献类型：
--
作者：
Fiorini, GS;Jeffries, GDM;Chiu, DT
由于各种有益的材料特性，可负担的成本以及从一系列不同类型的塑料中可用的直接制造方法，塑料越来越多地用于制造芯片实验室设备。聚二甲基硅氧烷（PDMS）器件的快速成型已成为研究实验室中快速简便制造微流控器件的一种众所周知的工艺；然而，PDMS并不总是适合所有应用的材料。本文介绍了热固性聚酯微流控装置的制造和热压模的复制成型技术。快速原型PDMS模具方便地用于生产非PDMS聚合物器件。所述铸造聚酯中的凹陷特征可与第二聚酯片粘合以形成封闭的微通道。热固性聚酯可以承受适度的压力和高温；因此，铸聚酯片也可以作为压花聚甲基丙烯酸甲酯（PMMA）微流控系统的母材。介绍了封闭聚酯和PMMA微通道的例子，并讨论了这两种类型通道的电渗透特性，这对毛细管电泳等分析应用很重要。
Plastics are increasingly being used for the fabrication of Lab-on-a-Chip devices due to the variety of beneficial material properties, affordable cost, and straightforward fabrication methods available from a range of different types of plastics. Rapid prototyping of polydimethylsiloxane (PDMS) devices has become a well-known process for the quick and easy fabrication of microfluidic devices in the research laboratory; however, PDMS is not always an appropriate material for every application. This paper describes the fabrication of thermoset polyester microfluidic devices and masters for hot embossing using replica molding techniques. Rapid prototyped PDMS molds are convienently used for the production of non-PDMS polymeric devices. The recessed features in the cast polyester can be bonded to a second polyester piece to form an enclosed microchannel. Thermoset polyester can withstand moderate amounts of pressure and elevated temperature; therefore, the cast polyester piece also can be used as a master for embossing polymethylmethacrylate (PMMA) microfluidic systems. Examples of enclosed polyester and PMMA microchannels are presented, and we discuss the electroosmotic properties of both types of channels, which are important for analytical applications such as capillary electrophoresis.