Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults.
Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults.
复制标题
DOI：
10.1155/2015/594039
复制
发表时间：
2015
影响因子：
4.6
通讯作者：
Daskalakis C
中科院分区：
文献类型：
--
作者：
Cheng C;Daskalakis C
内脏脂肪组织中的促炎性脂肪因子（炎症标志物）可引发胰岛素抵抗（IR）和内皮功能障碍（艾德）的发生。本研究的目的是研究5种炎症标志物（CRP和4种脂肪因子：IL-6、TNFα、派-1和脂联素）与IR（定量胰岛素抵抗检查指数（QUICKI））、微血管指标（毛细血管密度和白蛋白/肌酐比值（ACR））和内皮指标（前臂血流量（FBF）从静息基线增加至最大血管舒张）的相关性。通过多元线性回归进行分析。295名研究参与者年龄在18至45岁之间，没有糖尿病或高血压。他们包括24%的非洲裔美国人和21%的亚洲人，平均体重指数为25.4 kg/m2。所有五种炎症标志物均与QUICKI显著相关。除脂联素外，其他所有指标均与毛细血管密度显著相关，但均与ACR无关。最后，IL-6和派-1与FBF增加显著相关。我们还确定了正常体重和超重参与者中肥胖和IL-6之间的潜在相互作用：IL-6似乎与QUICKI和毛细血管密度呈正相关（有益作用），但在肥胖个体中则相反。这些研究结果表明，炎症指标可能是年轻无症状个体心血管风险的潜在早期标志物。
Proinflammatory adipokines (inflammation markers) from visceral adipose tissue may initiate the development of insulin resistance (IR) and endothelial dysfunction (ED). This study's objective was to investigate the association of five inflammation markers (CRP and four adipokines: IL-6, TNFα, PAI-1, and adiponectin) with IR (quantitative insulin resistance check index (QUICKI)), microvascular measures (capillary density and albumin-to-creatinine ratio (ACR)), and endothelial measures (forearm blood flow (FBF) increases from resting baseline to maximal vasodilation). Analyses were conducted via multiple linear regression. The 295 study participants were between 18 and 45 years of age, without diabetes or hypertension. They included 24% African Americans and 21% Asians with average body mass index of 25.4 kg/m2. All five inflammation markers were significantly associated with QUICKI. All but adiponectin were significantly associated with capillary density, but none were associated with ACR. Finally, IL-6 and PAI-1 were significantly associated with FBF increase. We also identified a potential interaction between obesity and IL-6 among normal-weight and overweight participants: IL-6 appeared to be positively associated with QUICKI and capillary density (beneficial effect), but the inverse was true among obese individuals. These study findings suggest that inflammation measures may be potential early markers of cardiovascular risk in young asymptomatic individuals.