The incidence of oesophageal cancer in Eastern Africa: Identification of a new geographic hot spot?
The incidence of oesophageal cancer in Eastern Africa: Identification of a new geographic hot spot?
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DOI：
10.1016/j.canep.2015.01.001
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发表时间：
2015-04-01
影响因子：
2.6
通讯作者：
Van Loon, Katherine
中科院分区：
文献类型：
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作者：
Cheng, Michael L.;Zhang, Li;Van Loon, Katherine
食管癌（OC）的发病率在地理上各不相同，全世界80%以上的病例和死亡发生在发展中国家。本研究的目的是描述在东非，这可能是一个以前未描述的高发病率地区的四个城市人口的OC的疾病负担。2004年至2008年诊断的所有OC病例的数据来自四个基于人口的癌症登记处：马拉维的布兰太尔;津巴布韦的哈拉雷;乌干达的坎帕拉;肯尼亚的内罗毕。计算每个人群的标准化发病率（ASR），并确定事件病例的描述性统计量。在布兰太尔，报告了351例男性（59%）和239例女性（41%）病例，ASR分别为47.2和30.3。在哈拉雷，报告了213例男性（61%）和134例女性（39%）病例，ASR分别为33.4和25.3。在坎帕拉，报告了196例男性（59%）和137例女性（41%）病例，ASR分别为36.7和24.8。在内罗毕，报告了323例男性（57%）和239例女性（43%）病例，ASR分别为22.6和21.6。四个人群中诊断时的中位年龄有显著差异，从布兰太尔的50岁到哈拉雷的65岁（p < 0.0001）。除内罗毕外，男性发病率明显高于女性（p < 0.01）。鳞状细胞癌是所有部位的主要组织学亚型。所有四个研究中心的ASR均显著高于全球平均ASR。需要进行调查，以评估饮食、生活方式、环境和其他影响该地区发病率的因素的潜在病因学影响。(C)2015爱思唯尔有限公司版权所有。
The incidence of oesophageal cancer (OC) varies geographically, with more than 80% of cases and deaths worldwide occurring in developing countries. The aim of this study is to characterize the disease burden of OC in four urban populations in Eastern Africa, which may represent a previously undescribed high-incidence area. Data on all cases of OC diagnosed between 2004 and 2008 were obtained from four population-based cancer registries in: Blantyre, Malawi; Harare, Zimbabwe; Kampala, Uganda; and Nairobi, Kenya. Age-standardized incidence rates (ASRs) were calculated for each population, and descriptive statistics for incident cases were determined. In Blantyre, 351 male (59%) and 239 (41%) female cases were reported, with ASRs of 47.2 and 30.3. In Harare, 213 male (61%) and 134 (39%) female cases were reported, with ASRs of 33.4 and 25.3, respectively. In Kampala, 196 male (59%) and 137 female (41%) cases were reported, with ASRs of 36.7 and 24.8. In Nairobi, 323 male (57%) and 239 female (43%) cases were reported, with ASRs of 22.6 and 21.6. Median age at diagnosis was significantly different among the four populations, ranging from 50 years in Blantyre to 65 years in Harare (p < 0.0001). Except in Nairobi, incidence among males was significantly higher than among females (p < 0.01). Squamous cell OC was the predominant histologic subtype at all sites. ASRs at all four sites were remarkably higher than the mean worldwide ASR. Investigation to evaluate potential etiologic effects of dietary, lifestyle, environmental, and other factors impacting the incidence in this region is needed. (C) 2015 Elsevier Ltd. All rights reserved.