End-expiratory carbon monoxide levels in healthy subjects living in a densely populated urban environment
End-expiratory carbon monoxide levels in healthy subjects living in a densely populated urban environment
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DOI：
10.1016/j.scitotenv.2005.02.018
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发表时间：
2006-02-01
影响因子：
9.8
通讯作者：
Lam, PKW
中科院分区：
文献类型：
--
作者：
Jones, AYM;Lam, PKW
一氧化碳（CO）对血红蛋白有很高的亲和力，是工业和家庭中毒的常见原因。呼吸系统疾病患者呼出的一氧化碳水平有报道，但按年龄和性别分组的一大群健康受试者呼出的一氧化碳水平未见报道。在一个大学校园和两个商业广场记录了1032名受试者呼出的一氧化碳水平和肺功能数据。受试者还被要求完成一份呼吸症状问卷。98名受试者报告有呼吸道疾病，并被排除在研究之外。非吸烟男性受试者（n = 508）呼出的CO水平（4.36 +/- 2.54 ppm）[范围0-21 ppm]高于女性受试者（n = 348） （3.72 +/- 2.12 ppm）[范围0-14 ppm] (p < 0.0005)，老年受试者（60岁以上）呼出的CO水平低于年轻受试者（< 22岁）（p = 0.018）。超过13%的非吸烟者呼出的二氧化碳含量超过7ppm。吸烟者呼出的CO含量明显高于非吸烟者（p < 0.0005），而抱怨经常咳嗽和咳痰的吸烟者呼出的CO含量高于没有此类抱怨的吸烟者。吸烟史（包年）与年龄呈正相关（r = 0.59），与第一秒用力呼气流量（FEV1） （r = -0.29）和呼气峰值流量（PEFR） （r = -0.25）呈负相关（p < 0.05）。如果一个城市的微环境CO浓度和人类活动模式是可用的，定期监测健康受试者呼出的CO有可能被用作空气污染的功能指数。(c) 2005 Elsevier B.V.版权所有
Carbon monoxide (CO) has a high affinity for haemoglobin and is a common cause of poisoning in industry and the home. Exhaled CO levels in patients with respiratory disease have been reported but exhaled CO in a large cohort of healthy subjects grouped by age and gender has not been reported. Exhaled CO levels and spirometry lung function data were recorded from 1032 subjects at a university campus and two commercial plazas. Subjects were also asked to complete a respiratory symptom questionnaire. Ninety-eight subjects reported respiratory disease and were excluded from the study. Non-smoking male subjects (n = 508) had higher exhaled CO levels (4.36 +/- 2.54 ppm) [range 0-21 ppm] compared with female (n = 348) subjects (3.72 +/- 2.12 ppm) [range 0-14 ppm] (p < 0.0005), and older subjects (> 60 years) had lower exhaled CO levels compared with young subjects (< 22 years) (p = 0.018). Over 13% of non-smokers had an exhaled CO greater than 7 ppm. Smokers showed significantly higher exhaled CO levels compared with non-smokers (p < 0.0005) and smokers who complained of frequent cough and sputum production had higher levels of exhaled CO compared with smokers without such complaints. Smoking history (pack-years) was directly related to age (r = 0.59) but correlated inversely with forced expiratory flow in the 1st second (FEV1) (r = -0.29) and peak expiratory flow rate (PEFR) (r = -0.25) (p < 0.05). If a city's micro environmental CO concentrations and human activity patterns is available, regular monitoring of exhaled CO in healthy subjects has the potential to be used as a functional index of air pollution. (c) 2005 Elsevier B.V. All rights reserved.