Serotonin modulates the central pattern generator for locomotion in the isolated lamprey spinal cord.
Serotonin modulates the central pattern generator for locomotion in the isolated lamprey spinal cord.
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发表时间：
1985-05
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通讯作者：
R. Harris-Warrick;A. Cohen
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作者：
R. Harris-Warrick;A. Cohen
通过在沐浴盐水中添加 D-谷氨酸，可以在体外激活七鳃鳗脊髓运动的中央模式发生器。单独沐浴时，血清素没有任何作用，但它可以调节 D-谷氨酸激活的游泳模式。观察到三个主要效应：节律性腹侧根爆发放电频率的剂量依赖性降低；爆发放电强度的增强，部分原因是先前不活跃的运动神经元的募集；段间相位滞后的延长。运动神经元的激活似乎是由中央模式发生器增强的突触驱动引起的。没有观察到血清素对运动神经元本身（静息电位、输入电阻或动作电位产生阈值）的直接影响。理论和实验研究表明，节间相位滞后的延长至少部分是由于血清素对脊髓不同部位节段振荡器的不同影响所致。孤立的尾部脊髓片比孤立的喙部片更容易受到血清素的影响。我们认为，血清素可能是七鳃鳗运动的中央模式发生器的内源性调节剂。它可能在通过单个中央模式生成器生成一系列相关波动运动（游泳、爬行、挖洞）中发挥作用。
The central pattern generator for locomotion in the spinal cord of the lamprey can be activated in vitro by the addition of D-glutamate to the bathing saline. Serotonin has no effects when bath-applied alone, but it modulates the D-glutamate-activated swimming pattern. Three major effects are observed: a dose-dependent reduction in the frequency of rhythmic ventral root burst discharge; enhancement of the intensity of burst discharge, due in part to the recruitment of previously inactive motoneurones; prolongation of the intersegmental phase lag. Motoneurone activation appears to result from enhanced synaptic drive from the central pattern generator; no direct effects of serotonin on the motoneurones themselves (resting potential, input resistance or threshold for action potential generation) were observed. Theoretical and experimental studies suggest that the prolongation of the intersegmental phase lag results at least in part from differential effects of serotonin on segmental oscillators in different parts of the spinal cord. Isolated caudal pieces of the cord were more strongly affected by serotonin than isolated rostral pieces. We propose that serotonin may be an endogenous modulator of the central pattern generator for locomotion in the lamprey. It may have a role in the generation of a family of related undulatory movements (swimming, crawling, burrowing) by a single central pattern generator.