ENDOTHELIAL-CELL MORPHOMETRY OF ATHEROSCLEROTIC LESIONS AND FLOW PROFILES AT AORTIC BIFURCATIONS IN CHOLESTEROL-FED RABBITS
ENDOTHELIAL-CELL MORPHOMETRY OF ATHEROSCLEROTIC LESIONS AND FLOW PROFILES AT AORTIC BIFURCATIONS IN CHOLESTEROL-FED RABBITS
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DOI：
10.1115/1.2891387
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发表时间：
1992-08-01
影响因子：
1.7
通讯作者：
YOSHIDA, Y
中科院分区：
文献类型：
--
作者：
OKANO, M;YOSHIDA, Y
在扫描电镜下观察了高脂血症家兔头臂动脉和左锁骨下动脉分叉处嗜苏丹区和非嗜苏丹区内皮细胞的形态。血流的停滞点和分流器的前缘是非嗜苏丹性的，分别被圆形和长梭形内皮细胞覆盖。两个分支的分流器的臀部，被证明是相对较低的剪切应力区，通过微球在稳定流中的运动，是嗜苏丹的，被椭圆形细胞覆盖。在血脂正常的家兔中进行了类似的研究。可以得出结论，高脂血症兔的脂质沉积发生在相对低的剪切应力区域，在那里内皮细胞功能激活，而不是在层流高剪切应力区域的分流器。
Observations on shapes of endothelial cells both in sudanophilic and nonsudanophilic regions at bifurcations of the brachiocephalic (BC) and left subclavian (SA) arteries in hyperlipidemic rabbits were performed under a SEM. The stagnation point of flow and leading edges of flow dividers were nonsudanophilic and covered by round and long fusiform endothelial cells, respectively. The hips of flow dividers of both branchings, proven to be relatively low shear stress regions, by movement of microspheres in steady flow, were sudanophilic and covered by ellipsoidal cells. Similar studies were carried out in normolipidemic rabbits. It might be concluded that lipid deposition in hyperlipidemic rabbits occurs in relatively low shear stress regions, where endothelial cells are functionally activated, rather than in laminar high shear stress regions at the flow divider.