A simple technique for monitoring the synaptic actions of pharmacological agents.
A simple technique for monitoring the synaptic actions of pharmacological agents.
复制标题
一种监测药物突触作用的简单技术。
DOI：
--
复制
发表时间：
1973
影响因子：
2.8
通讯作者：
D. Sattelle
中科院分区：
文献类型：
--
作者：
J. Callec;D. Sattelle
1.本文介绍了一种用于昆虫突触传递药理学研究的简单电生理学方法。2.用该技术记录了美洲大蠊第六腹神经节的突触电位和神经节极化。很长时间。3.在没有刺激的情况下，可以记录自发兴奋性（EPSP）和抑制性（IPSP）突触后电位。机械刺激cercal受体证明了导致锋电位产生的EPSP的总和。4.对颈神经（X，XI）的电刺激使得能够记录单突触EPSP（XI）和双突触IPSP（X）。5.乙酰胆碱对突触传递的作用，包括剂量反应曲线，进行了描述。6.这种技术作为一种工具，在药理学研究的潜力进行了讨论。
1. A simple electrophysiological method for the pharmacological investigation of synaptic transmission in insects is described. 2. By means of this technique synaptic potentials and ganglionic polarization can be recorded from the sixth abdominal ganglion of Periplaneta americana L. for long periods. 3. In the absence of stimulation, spontaneous excitatory (EPSP) and inhibitory (IPSP) postsynaptic potentials can be recorded. The mechanical stimulation of cercal receptors demonstrates the summation of EPSPs leading to spike generation. 4. Electrical stimulation of the cercal nerves (X, XI) enables the recording of a monosynaptic EPSP (XI) and a bisynaptic IPSP (X). 5. The action of acetylcholine on synaptic transmission, including a dose-response curve, is described. 6. The potential of this technique as a tool in pharmacological research is discussed.