Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis
Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis
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DOI：
10.1111/wrr.12398
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发表时间：
2016-03-01
影响因子：
2.9
通讯作者：
Falanga, Vincent
中科院分区：
文献类型：
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作者：
Lichtman, Michael K.;Otero-Vinas, Marta;Falanga, Vincent
疤痕的形成，伴随着正常组织结构的持续改变，是伤口愈合和纤维化疾病的一个不希望的和重要的结果。很少有预防或治疗疤痕的策略。转化生长因子β (tgf - β)超家族是组织修复的重要介质。每种tgf - β亚型可能对伤口愈合产生不同的影响，这可能与环境有关。特别是，tgf - β 1可能介导成人伤口纤维化，而tgf - β 3可能促进胎儿无瘢痕愈合，减少成人瘢痕形成。因此，tgf - β 3可能为急慢性伤口和纤维化疾病提供减少疤痕的治疗。
Scar formation, with persistent alteration of the normal tissue structure, is an undesirable and significant result of both wound healing and fibrosing disorders. There are few strategies to prevent or to treat scarring. The transforming growth factor beta (TGF-beta) superfamily is an important mediator of tissue repair. Each TGF-beta isoform may exert a different effect on wound healing, which may be context-dependent. In particular, TGF-beta 1 may mediate fibrosis in adults' wounds, while TGF-beta 3 may promote scarless healing in the fetus and reduced scarring in adults. Thus, TGF-beta 3 may offer a scar-reducing therapy for acute and chronic wounds and fibrosing disorders.