Esophageal eosinophilia in children with dysphagia
Esophageal eosinophilia in children with dysphagia
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DOI：
10.1097/00005176-200310000-00018
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发表时间：
2003-10-01
影响因子：
2.9
通讯作者：
Chow, CW
中科院分区：
文献类型：
--
作者：
Cheung, KM;Oliver, MR;Chow, CW
目的：儿童偶尔会在没有明显主要原因的情况下出现吞咽困难。有时在这些患者进行上消化道内窥镜检查时会发现食管嗜酸性粒细胞增多，但其意义尚不清楚。尽管嗜酸性粒细胞增多被一些人认为是儿童反流性食管炎的组织学标志，但实际上它可能预示着吞咽困难儿童的原发性嗜酸性粒细胞性食管炎。我们的目的是评估以吞咽困难为主要主诉的儿童的食管炎、pH 探针测定的胃酸反流和食管嗜酸性粒细胞增多。方法：对 42 名因吞咽困难入院检查但未找到主要原因的儿童进行回顾性研究。 21 名儿童（平均年龄 +/- SD，10.1 +/- 4.0 岁）患有食管嗜酸性粒细胞增多症，21 名儿童（8.3 +/- 4.7 岁）则没有。比较两组的临床、内镜、测压和食管 pH 参数。结果：食管嗜酸性粒细胞增多的患者多为男性（p
Objectives: Children occasionally have dysphagia in the absence of an apparent primary cause. Esophageal eosinophilia is sometimes seen in these patients at the time of upper endoscopy but its significance is not clear. Although eosinophilia is regarded by some as a histologic hallmark of childhood reflux esophagitis, it may in fact signal a primary eosinophilic esophagitis in children with dysphagia. Our aim was to evaluate esophagitis, acid reflux determined by pH probe, and esophageal eosinophilia in children with the primary complaint of dysphagia.Methods: A retrospective study was performed in 42 children, admitted for investigation of dysphagia, in whom no primary cause could be found. Twenty-one children (mean age +/- SD, 10.1 +/- 4.0 years) had esophageal eosinophilia and 21 children (8.3 +/- 4.7 years) did not. Clinical, endoscopic, manometric and esophageal pH parameters in these two groups were compared.Results: Patients with esophageal eosinophilia were more often male (p