A retrospective cohort study
A retrospective cohort study
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发表时间：
2021
影响因子：
6.2
通讯作者：
M. Chua;Linjie Bianb;Jie-Sheng Huanga;Yigang Chenc;D. Wub;Hao Wangd
中科院分区：
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作者：
M. Chua;Linjie Bianb;Jie-Sheng Huanga;Yigang Chenc;D. Wub;Hao Wangd
自2019年12月武汉报告首例冠状病毒病(新冠肺炎)病例以来，中国，该病毒迅速传播，影响了全球数以百万计的人。本研究的目的是调查分析无锡地区新冠肺炎感染者的临床特征和转归。横断面研究。无锡市第五人民医院中国。研究对象为2020年1月23日至2020年3月8日期间入选的48例新冠肺炎患者，收集其临床资料。收集和分析流行病学、临床、实验室和放射学特征，以及治疗和结果数据。确诊的48例新冠肺炎患者中，轻度3例(6.3%)，中度44例(91.7%)，重度1例(2.1%)。受试者的中位年龄为45岁(四分位数范围[IQR]，24-59岁；5-75岁)。男性25例(52.1%)，女性23例(47.9%)。28例(58.3%)返回江苏无锡。聚集性感染34例(70.8%)，家庭聚集性感染29例(85.3%)。队列中除3例轻度外，其余患者均未见明显临床症状。最常见的症状包括发热(41例(85.4%))、咳嗽(28例(58.3%))、乏力(13例(27.1%))、咳痰(11例(22.9%))、腹泻(10例(20.8%))和呼吸困难(5例(10.4%))。17例(35.4%)患者淋巴细胞值低于基础值，31例(64.6%)D-二聚体高于正常范围。高分辨率CT阳性病变分布：左肺5例(10.4%)，右肺9例(18.8%)，双肺31例(64.6%)。病变密度：肺内毛玻璃影28例(58.3%)，实性密度影7例(14.6%)，混合密度影10例(20.8%)。肺外表现：纵隔淋巴结肿大2例(4.2%)，胸腔积液1例(2.1%)。所有患者均接受隔离治疗。抗病毒治疗45例(93.8%)，抗菌治疗22例(45.8%)，糖皮质激素治疗6例(12.5%)，高流量吸氧治疗2例(4.2%)，无创呼吸机治疗6例(12.5%)。截至2020年3月8日，纳入本研究的48名患者全部治愈。48例患者平均住院时间为18±6(平均±SD)d，平均皮损吸收时间为11±4 d，平均(10±4)d核酸检查结果为阴性。无锡市48例新冠肺炎患者的流行病学特征以输入性病例和聚集性病例为主。这些患者的临床表现主要是发热和咳嗽。实验室结果显示，淋巴细胞减少和D二聚体升高与疾病严重程度呈正相关。肺部影像表现为单侧或双侧毛玻璃浸润。大部分患者在入院后15天内进入临床恢复期。编辑：Mohammed Nader Shalaby。间充质干细胞外切体雾化治疗新型冠状病毒肺炎(N2020X008)关键技术研究两位作者没有利益冲突要披露。在本研究期间产生和/或在本研究期间分析的数据集，如有合理要求，可从相应的作者处获得。南京医科大学附属无锡第二人民医院呼吸与危重病内科，放射科b科，普外科c科，d锡瑞干细胞科技有限公司，江苏214002，PR中国。∗通讯：南京医科大学附属无锡第二人民医院普外科陈一刚，邮编：214002，PR中国(邮箱：wuxichen2512@njmu.edu.cn)。版权所有©2021作者(S)。由Wolters Kluwer Health，Inc.发布。这是一篇开放获取的文章，根据知识共享署名-非商业许可4.0(CCBY-NC)的条款分发，其中允许下载、共享、混音、转换和构建作品，前提是它被正确引用。未经《华尔街日报》许可，该作品不得用于商业用途。如何引用这篇文章：储明，边L，黄静，陈勇，吴丁，王浩。无锡市48例新冠肺炎感染住院患者的临床特征和预后：一项回顾性队列研究。《医学》2021；100：5(E23991)。收到日期：2020年9月5日/最终收到日期：2020年11月22日/接受日期：2020年11月28日http://dx.doi.org/10.1097/MD.0000000000023991
Since the first infected case of Coronavirus Disease 2019 (COVID-19) was reported inWuhan, China in December 2019, the virus has spread swiftly, inflicting upon millions of people around the globe. The objective of the study is to investigate and analyze the clinical characteristics and outcomes of patients infected with COVID-19 in Wuxi, China. Cross-sectional study. The Fifth People’s Hospital of Wuxi, China. A total of 48 COVID-19 patients were enrolled in the study from 23 January 2020 to 8 March 2020, and the clinical data of these subjects were collected. Epidemiological, clinical, laboratory, and radiologic characteristics, as well as treatment and outcome data, were collected and analyzed. Of these 48 patients with confirmed COVID-19, 3 were mild cases (6.3%), 44 were moderate cases (91.7%), 1 was severe case (2.1%). The median age of the subjects was 45 years (interquartile range [IQR], 24–59; range, 5–75 years). Twenty-five of the patients (52.1%) were male and 23 (47.9%) were female. Twenty-eight cases (58.3%) returned to Wuxi, Jiangsu Province. Thirty-four (70.8%) cases were infected due to clustering epidemic and 29 cases (85.3%) were attributable to family-clustering epidemic. No obvious clinical symptoms were observed in the cohort of patients, except for 3 mild cases. The most common symptoms include fever (41 [85.4%]), cough (28 [58.3%]), asthenia (13 [27.1%]), expectoration (11 [22.9%]), diarrhea (10 [20.8%]), and dyspnea (5 [10.4%]). Seventeen (35.4%) patients had lower lymphocyte values than baseline, 31 patients (64.6%) had higher D-dimers to exceed the normal range. The distribution of high-resolution computed tomography (HRCT)-positive lesions were as follows: left lung in 5 cases (10.4%), right lung in 9 cases (18.8%), and bilateral lungs in 31 cases (64.6%). In terms of density of lesions: 28 cases (58.3%) showed ground glass shadows in the lung, 7 cases (14.6%) showed solid density shadows, and 10 cases (20.8%) showed mixed density shadows. Extrapulmonary manifestations found that mediastinal lymph nodes were enlarged in 2 cases (4.2%) and that pleural effusion was present in 1 case (2.1%). All patients underwent treatment in quarantine. Forty-five (93.8%) patients received antiviral treatments, 22 (45.8%) patients received antibacterial treatments, 6 (12.5%) patients received glucocorticoid treatments, 2 (4.2%) patients received high flow oxygen inhalation treatments, and 6 (12.5%) patients received noninvasive ventilation treatments. As of 8 March 2020, all 48 patients included in this study were cured. The average time of hospitalization of the 48 patients was 18±6 (mean±SD) days, the average time of the lesion resorption was 11±4 days, and the average time taken to achieve negativity in the result of nucleic acid examination was (10±4) days. The epidemiological characteristics of 48 COVID-19 patients in Wuxi were mainly imported cases and clustered cases. The clinical manifestations of these patients were mainly fever and cough. Laboratory results showed that the lymphocytopenia and increased Ddimer are positively correlated with disease severity. Pulmonary imaging showed unilateral or bilateral ground glass infiltration. Most of the patients entered clinical recovery stage within 15 days after hospitalization. Editor: Mohammed Nader Shalaby. Study on the Key Techniques of Nebulization of Mesenchymal Stem Cell Exosomes for the Treatment of Novel Coronavirus Pneumonia (N2020X008). The authors have no conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. a Department of Respiratory and Critical Care Medicine, Wuxi Fifth People’s Hospital, b Department of Radiology, c Department of General Surgery, The Affiliated Wuxi No. 2 People’s Hospital of Nanjing Medical University, d Xirui Stem Cell Technology Co., Ltd, Jiangsu 214002, PR China. ∗ Correspondence: Yigang Chen, Department of General Surgery, The Affiliated Wuxi No. 2 People’s Hospital of Nanjing Medical University, 68 Zhongshan Road, Jiangsu 214002, PR China (e-mail: wuxichen2512@njmu.edu.cn). Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. How to cite this article: Chu M, Bian L, Huang J, Chen Y, Wu D, Wang H. Clinical characteristics and outcomes of 48 patients hospitalized for COVID-19 infection in Wuxi: A retrospective cohort study. Medicine 2021;100:5(e23991). Received: 5 September 2020 / Received in final form: 22 November 2020 / Accepted: 28 November 2020 http://dx.doi.org/10.1097/MD.0000000000023991