Influence of radiation quality on the effectiveness of small doses for induction of reproductive death and chromosome aberrations in mammalian cells.
Influence of radiation quality on the effectiveness of small doses for induction of reproductive death and chromosome aberrations in mammalian cells.
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辐射质量对小剂量诱导哺乳动物细胞生殖死亡和染色体畸变有效性的影响。
DOI：
10.1080/09553007914550811
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
G. Barendsen
中科院分区：
文献类型：
--
作者：
G. Barendsen
分析和解释发表的数据有关的辐射生物学效应的依赖性的辐射质量的光子，中子和重离子的诱导这两种效果在不同类型的哺乳动物细胞。该分析的结果表明，在有丝分裂中观察到的染色体畸变显示出比细胞失活更强的对YF或LET无穷大的依赖性。在高YF下，可观察到的畸变对小剂量诱导的细胞生殖死亡起主要作用。在低YF下，小剂量对细胞死亡的有效性主要取决于另一种类型的损伤，可能也在染色体中诱导，但在有丝分裂中不可观察到。这种类型的损伤比可观察到的像差更少地依赖于YF或LET无穷大。这些差异的影响，在有关辐射质量的其他类型的损害的数据外推到感兴趣的小剂量辐射防护的损害的关系进行了讨论最大r.b.e值。
An analysis and interpretation is presented of published data concerning the dependence of radiobiological effectiveness on the radiation quality of photons, neutrons and heavy ions for the induction of these two effects in different types of mammalian cell. The results of this analysis suggest that chromosome aberrations observable at mitosis show a stronger dependence on YF or LET infinity than cell inactivation. At high YF, observable abberrations provide a major contribution to cell reproductive death induced by small doses. At low YF the effectiveness of small doses for cell death depends mainly on another type of damage, possibly also induced in the chromosomes, but not observable at mitosis. This type of damage depends less of YF or LET infinity than observable aberrations. The implications of these differences in damage in relation to radiation quality for the extrapolation of data on other types of damage to small doses of interest in radiation protection are discussed in relation to maximum r.b.e values observed.