Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women The Japan Collaborative Cohort Study
Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women The Japan Collaborative Cohort Study
复制标题
DOI：
10.1161/strokeaha.108.520288
复制
发表时间：
2008-11-01
期刊：
影响因子：
8.3
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Ikehara, Satoyo;Iso, Hiroyasu;Tamakoshi, Akiko
背景和目的-先前的研究已经证明了饮酒与心血管疾病死亡率之间的关系。然而，酒精消费和中风和冠心病的死亡率之间的性别特异性关联仍然不清楚。方法，在1988年和1990年之间，34 776名男性和48 906名女性年龄在40至79岁完成了自我管理的问卷调查，包括有关酒精消费的信息。他们进行了为期14.2 years的中位随访。结果在83682名受访者中，1628人死于中风，736人死于冠心病。对于男性，大量饮酒（>= 46.0 g乙醇/天）与总中风、出血性中风和缺血性中风的死亡率增加相关，而与不饮酒相比，轻度至中度饮酒与总心血管疾病的死亡率降低相关。总体斯托克、出血性卒中、缺血性卒中和总体心血管疾病的多变量风险比（95% CI）分别为1.48（1.22 - 1.80）、1.67（1.17 - 2.38）、1.35（1.04 - 1.75）和0.88（0.78 - 1.00）。大量饮酒（≥ 46.0 g乙醇/天）的女性冠心病死亡率增加，与不饮酒者相比，每天饮酒0.1 - 22.9 g乙醇的女性总心血管疾病死亡率降低。两类饮酒者的多变量风险比（95%CI）分别为4.10（1.63至10.3）和0.75（0.62 ~ 0.91）.结论-大量饮酒与男性总中风，特别是出血性中风和总心血管疾病的死亡率增加有关，与女性冠心病的死亡率增加有关，而轻度至中度饮酒可能与男女心血管疾病死亡率的降低有关。（中风。2008; 39：2936-2942）。
Background and Purpose-Previous studies have demonstrated the association between alcohol consumption and cardiovascular mortality. However, the sex-specific association between alcohol consumption and mortality from stroke and coronary heart disease remains unclear.Methods-Between 1988 and 1990, 34 776 men and 48 906 women aged 40 to 79 years completed a self-administered questionnaire including information about alcohol consumption. They were followed-up for a median duration of 14.2 years.Results-Of the 83 682 respondents, 1628 died from stroke and 736 died from coronary heart disease. For men, heavy drinking (>= 46.0 g ethanol/day) was associated with increased mortality from total, hemorrhagic, and ischemic strokes, whereas light-to-moderate drinking was associated with reduced mortality from total cardiovascular disease, compared with not drinking. The respective multivariable hazard ratios (95% CI) were 1.48 (1.22 to 1.80) for total stoke, 1.67 (1.17 to 2.38) for hemorrhagic stroke, 1.35 (1.04 to 1.75) for ischemic stroke, and 0.88 (0.78 to 1.00) for total cardiovascular disease. Women who were heavy drinkers (>= 46.0 g ethanol/day) showed increased mortality from coronary heart disease, and there was reduced mortality from total cardiovascular disease for drinkers of 0.1 to 22.9 g ethanol per day compared with mortality for nondrinkers. The respective multivariable hazard ratios (95% CI) for the 2 categories of drinkers were 4.10 (1.63 to 10.3) and 0.75 (0.62 to 0.91).Conclusions-Heavy alcohol consumption is associated with increased mortality from total stroke, particularly hemorrhagic stroke, and total cardiovascular disease for men, and from coronary heart disease for women, whereas light-to-moderate drinking may be associated with reduced mortality from cardiovascular disease for both sexes. (Stroke. 2008; 39: 2936-2942.)