BRAIN-SPECIFIC GENES HAVE IDENTIFIER SEQUENCES IN THEIR INTRONS
BRAIN-SPECIFIC GENES HAVE IDENTIFIER SEQUENCES IN THEIR INTRONS
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DOI：
10.1073/pnas.81.3.713
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
SUTCLIFFE, JG
中科院分区：
文献类型：
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作者：
MILNER, RJ;BLOOM, FE;SUTCLIFFE, JG
82个核苷酸的标识符(ID)序列在大鼠基因组中存在1-1.5倍。大脑特异性 mRNA 前体的 105 个拷贝和 c[互补]DNA 克隆。一种大脑特异性基因的内含子中含有超过 1 个 ID 序列。大脑基因中存在过量的 ID 序列，并且一些 ID 序列似乎已作为移动元件插入到其他遗传位置中。脑基因的内含子中含有ID序列，但并非所有ID序列都位于脑基因内含子中。通过比较8个ID核苷酸序列获得大脑ID共有序列。
The 82-nucleotide identifier (ID) sequence is present in the rat genome in 1-1.5 .times. 105 copies and in c[complementary]DNA clones of precursors of brain-specific mRNA. One brain-specific gene contains more than 1 ID sequence in its introns. There is an excess of ID sequences to brain genes, and some ID sequences appear to have been inserted as mobile elements into other genetic locations. Brain genes contain ID sequences in their introns, but not all ID sequences are located in brain gene introns. A brain ID consensus sequence was obtained by comparing 8 ID nucleotide sequences.