Why bicarbonate?

Why bicarbonate?
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DOI:
10.1139/o06-184
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发表时间:
2006-12-01
影响因子:
2.9
通讯作者:
Casey, Joseph R.
Casey, Joseph R.
中科院分区:
生物学3区
文献类型:
--
作者:
Casey, Joseph R.

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双碳酰亚胺是一种简单的单碳分子,在各种生物过程中发挥着令人惊讶的重要作用。其中包括光合作用、克雷布斯循环、全身和细胞pH调节以及体积调节。由于碳酸氢盐是带电的,因此它对脂质双层是不可渗透的。因此,哺乳动物膜含有碳酸氢盐转运蛋白,以促进HCO 3-的特异性跨膜运动。本文综述了碳酸氢盐及其膜转运蛋白的生物化学,揭示了是什么使碳酸氢盐转运的研究成为一项有益的活动。
Bicarbonate is a simple single carbon molecule that plays surprisingly important roles in diverse biological processes. Among these are photosynthesis, the Krebs cycle, whole-body and cellular pH regulation, and volume regulation. Since bicarbonate is charged it is not permeable to lipid bilayers. Mammalian membranes thus contain bicarbonate transport proteins to facilitate the specific transmembrane movement of HCO3-. This review provides a wide-ranging view of the biochemistry of bicarbonate and its membrane transporters, revealing what makes the study of bicarbonate transport such a rewarding activity.