Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis
Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis
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DOI：
10.1016/j.bbapap.2009.09.008
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发表时间：
2010-03-01
影响因子：
3.2
通讯作者：
Av-Gay, Yossef
中科院分区：
文献类型：
--
作者：
Chao, Joseph;Wong, Dennis;Av-Gay, Yossef
结核分枝杆菌（Mycobacterium tuberculosis，Mtb）是结核病（TB）的病原体，其通过一套复杂的策略逃避宿主的抗微生物防御并在感染个体内存活。这些包括主动预防宿主细胞杀伤过程以及压倒性的适应性基因表达。在过去的十年中，我们已经获得了更多的了解分枝杆菌如何不仅有能力适应不断变化的宿主环境，而且还积极干扰宿主细胞内的信号机制，以抵消或抑制巨噬细胞所使用的部分杀伤装置。结核分枝杆菌能够通过一组磷酸化信号蛋白来感知其环境，这些蛋白以协调的方式介导其反应和与宿主的相互作用。在这篇综述中，我们总结了目前的知识选择结核分枝杆菌丝氨酸，苏氨酸和酪氨酸激酶和磷酸酶信号蛋白，集中在蛋白激酶，PknG和PtkA，和蛋白磷酸酶，PtpA。(C)2009爱思唯尔有限公司版权所有。
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), evades the antimicrobial defenses of the host and survives within the infected individual through a complex set of strategies. These include active prevention of host cellular killing processes as well as overwhelming adaptive gene expression. In the past decade, we have gained an increased understanding of how mycobacteria not only have the ability to adapt to a changing host environment but also actively interfere with the signaling machinery within the host cell to counteract or inhibit parts of the killing apparatus employed by the macrophage. Mtb is able to sense its environment via a set of phospho-signaling proteins which mediate its response and interaction with the host in a coordinated manner. In this review, we summarize the current knowledge about selected Mtb serine, threonine, and tyrosine kinase and phosphatase signaling proteins, focusing on the protein kinases, PknG and PtkA, and the protein phosphatase, PtpA. (C) 2009 Elsevier B.V. All rights reserved.