A new form of long-term depression in the perirhinal cortex
A new form of long-term depression in the perirhinal cortex
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DOI：
10.1038/72093
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发表时间：
2000-02-01
影响因子：
25
通讯作者：
Bashir, ZI
中科院分区：
文献类型：
--
作者：
Cho, K;Kemp, N;Bashir, ZI
我们证明了一种形式的长期抑郁症（LTD）在嗅周皮层，依赖于不同的谷氨酸受体之间的相互作用。II组代谢型谷氨酸（mGlu）受体促进1组mGlu受体介导的细胞内钙增加。这种便利加上NMDA受体激活可能是必要的诱导LTD在静息膜电位。然而，去极化增强NMDA受体的功能，并删除了第一组和第二组mGlu受体之间的协同作用的要求：在这些条件下，激活只有NMDA和第一组mGlu受体所需的LTD。这种谷氨酸受体的相互作用可能提供新的规则突触可塑性。这些形式的LTD发生在嗅周皮层，在那里神经元反应性的长期降低可能介导识别记忆。
We demonstrate a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between different glutamate receptors. Group II metabotropic glutamate (mGlu) receptors facilitated group 1 mGlu receptor-mediated increases in intracellular calcium. This facilitation plus NMDA receptor activation may be necessary for induction of LTD at resting membrane potentials. However, depolarization enhanced NMDA receptor function and removed the requirement of synergy between group I and group II mGlu receptors: under these conditions, activation of only NMDA and group I mGlu receptors was required for LTD. Such glutamate receptor interactions potentially provide new rules for synaptic plasticity. These forms of LTD occur in the perirhinal cortex, where long-term decreases in neuronal responsiveness may mediate recognition memory.