Destruction of the auditory thalamus disrupts the production of fear but not the inhibition of fear conditioned to an auditory stimulus.
Destruction of the auditory thalamus disrupts the production of fear but not the inhibition of fear conditioned to an auditory stimulus.
复制标题
听觉丘脑的破坏会扰乱恐惧的产生，但不会扰乱听觉刺激引起的恐惧的抑制。
DOI：
10.1016/s0006-8993(98)01047-6
复制
发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
Falls,WA
中科院分区：
文献类型：
--
作者：
Heldt,SA;Falls,WA
听觉丘脑是调节对听觉刺激的恐惧表达的神经回路的一部分。听觉丘脑的双侧损伤阻止了对伴随休克的听觉刺激的恐惧表达。本研究评估了双侧听觉丘脑的病变是否也会破坏对听觉刺激的恐惧抑制与休克的存在配对。给大鼠双侧听觉丘脑病变，然后进行巴甫洛夫条件抑制训练，其中光与休克配对，在没有休克的情况下，呈现噪声和光复合物。恐惧和恐惧的抑制测量与恐惧增强惊吓效应。听觉丘脑的病变并没有破坏噪音抑制恐惧对光的表达的能力。然而，这些损伤确实破坏了噪音在随后与休克配对后产生恐惧增强惊吓的能力。这些结果表明，虽然听觉丘脑是一个神经回路的一个重要组成部分，介导的表达恐惧的听觉刺激，它不是一个重要的组成部分的电路，介导的抑制恐惧的听觉刺激。
The auditory thalamus is part of a neural circuit that mediates the expression of fear to auditory stimuli. Bilateral lesions of the auditory thalamus prevent the expression of fear to an auditory stimulus paired with shock. The present study assessed whether bilateral lesions of the auditory thalamus would also disrupt the inhibition of fear to an auditory stimulus paired with the absence of shock. Rats were given bilateral lesions of the auditory thalamus followed by Pavlovian conditioned inhibition training in which a light was paired with shock and a noise and light compound was presented in the absence of shock. Fear and the inhibition of fear were measured with the fear-potentiated startle effect. Lesions of the auditory thalamus did not disrupt the ability of the noise to inhibit the expression of fear to the light. However, these lesions did disrupt the ability of the noise to produce fear-potentiated startle after it had been subsequently paired with shock. These results suggest that although the auditory thalamus is an essential part of a neural circuit that mediates the expression of fear to auditory stimuli, it is not an essential part of the circuit that mediates the inhibition of fear to auditory stimuli.