Influence of anabolic steroid on anxiety levels in sedentary male rats
Influence of anabolic steroid on anxiety levels in sedentary male rats
复制标题
合成代谢类固醇对久坐雄性大鼠焦虑水平的影响
DOI：
10.1080/10253890701281344
复制
发表时间：
2007
期刊：
影响因子：
2.3
通讯作者：
F. K. Marcondes
中科院分区：
文献类型：
--
作者：
V. Rocha;C. M. Calil;R. Ferreira;M. Moura;F. K. Marcondes
本研究的目的是评估癸酸诺龙对大鼠焦虑水平的影响。雄性Wistar大鼠用癸酸诺龙（5 mg/kg，每周2次，i.m.）或媒介物（丙二醇-0.2ml/kg，每周两次，IM）持续6周。对照大鼠仅接受与其常规饲养相关的程序。在6周结束时，对所有组（24-29只大鼠/组）进行高架十字迷宫测试以评估它们的焦虑水平。这些动物中的一些（12- 14只/组）用地西泮（lmg/kg i. p.）高架十字迷宫试验前30 min。与对照组（3.80 ± 0.97%）和溶剂组（3.96 ± 0.85%）相比，癸酸诺龙显著降低了在开放臂中花费的时间百分比（1.46 ± 0.49%），对照组和溶剂组之间无差异。与媒介物和对照相比，在用癸酸诺龙处理的组中开放臂进入的百分比也降低。未检测到闭合臂进入数量的变化。地西泮消除了癸酸诺龙对开放臂中的时间百分比和进入的影响。目前的研究表明，长期使用高剂量的癸酸诺龙会增加雄性大鼠的焦虑水平。
The aim of this study was to evaluate the influence of nandrolone decanoate on anxiety levels in rats. Male Wistar rats were treated with nandrolone decanoate (5mg/kg, two times per week, i.m.) or vehicle (propylene glycol—0.2 ml/kg, two times per week, IM) for 6 weeks. Control rats were subject only to procedures related to their routine husbandry. By the end of 6 weeks, all groups (24–29 rats/group) were submitted to the elevated plus maze test in order to evaluate their anxiety level. Some of these animals (12– 14/group) were treated with diazepam (1 mg/kg i.p.) 30 min before the elevated plus maze test. Nandrolone decanoate significantly decreased the percentage of time spent in the open arms (1.46 ± 0.49%) compared with control (3.80 ± 0.97%) and vehicle (3.96 ± 0.85%) groups, with no difference between control and vehicle treatments. The percentage of open arm entries was also reduced in the group treated with nandrolone decanoate in comparison with the vehicle and control. No changes in the number of closed arm entries were detected. Diazepam abolished the effects of nandrolone decanoate on the percentage of time in, and entries into the open arms. The present study showed that chronic treatment with a high dose of nandrolone decanoate increased the anxiety level in male rats.
八名举重运动员对合成代谢雄激素类固醇的身体和心理依赖的证据。
DOI：
10.1176/ajp.147.4.510
发表时间：
1990
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brower,KJ;Eliopulos,GA;Blow,FC;Catlin,DH;Beresford,TP
通讯作者：
Beresford,TP