Estradiol, but not dihydrotestosterone, in the medial amygdala facilitates male hamster sex behavior.
Estradiol, but not dihydrotestosterone, in the medial amygdala facilitates male hamster sex behavior.
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内侧杏仁核中的雌二醇（而非二氢睾酮）促进雄性仓鼠的性行为。
DOI：
10.1016/0031-9384(95)02204-x
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发表时间：
1996
影响因子：
2.9
通讯作者：
Wood,RI
中科院分区：
文献类型：
--
作者：
Wood,RI
在雄性叙利亚仓鼠中，内侧杏仁核（Me）和内侧视前区（MPOA）是表达雄性交配行为的关键。这些区域含有类固醇受体神经元，这些神经元传递交配所必需的激素信号。在MPOA内植入类固醇的去势男性中，睾酮或雌二醇可促进性活动。但是，DHT没有效果。Texetine也可以刺激交配时，植入在ME.The本研究确定，如果雌二醇或双氢睾酮在ME.Twenty成年雄性仓鼠的行为活动选择了激烈的性行为。去势后12周，评估性行为，并将每只雄性动物接受一个颅内植入物（23号管，填充有结晶雌二醇或DHT，每种n = 10），立体定位放置在后Me（MeP）中。手术后检查行为，以确定MeP中的雄激素或雌激素是否能刺激高于去势后观察到的性行为。植入DHT的雄性的交配行为与阉割的雄性没有显着差异。然而，男性雌二醇植入显示显着更多的交配和非交配的性活动后，手术与双氢睾酮植入相比。这些结果表明，睾酮促进交配行为的MeP是介导的芳构化雌二醇，而DHT是不行为活跃在这个核。
In the male Syrian hamster, the medial amygdaloid nucleus (Me) and medial preoptic area (MPOA) are critical for expression of male mating behavior. These regions contain steroid receptor-containing neurons that transduce hormonal signals essential for copulation. In castrated males bearing an intracerebral steroid implant in the MPOA, testosterone or estradiol can facilitate sexual activity. However, DHT is without effect. Testosterone can also stimulate mating when implanted in the Me. The present study determined if estradiol or DHT had behavioral activity in the Me. Twenty adult male hamsters were selected for vigorous sexual behavior. Twelve weeks after castration, sexual behavior was assessed and each male received a single intracranial implant (23-gauge tubing packed with crystalline estradiol or DHT, n = 10 each) placed stereotaxically into posterior Me (MeP). Behavior was examined after surgery to determine if androgens or estrogens in MeP could stimulate sexual behavior above that observed after castration. Mating behavior in DHT-implanted males was not significantly different from castrates. However, males with estradiol implants displayed significantly more copulatory and noncopulatory sexual activity after surgery compares to males with DHT implants. These results suggest that testosterone facilitation of mating behavior in MeP is mediated by aromatization to estradiol, and that DHT is not behaviorally active in this nucleus.