Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases.
Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases.
复制标题
DOI：
10.1007/s12026-015-8694-5
复制
发表时间：
2015-12
影响因子：
4.4
通讯作者：
Kim SJ
中科院分区：
文献类型：
--
作者：
Kim SJ
先前的研究已经确定了转录因子B淋巴细胞诱导的成熟蛋白-1（Blimp-1）在各种适应性免疫细胞类型如T和B淋巴细胞中的免疫功能。最近，已经表明Blimp-1将其功能作用扩展到树突状细胞（DC）和巨噬细胞，这两种细胞类型属于先天免疫系统。该蛋白分别通过募集染色质修饰因子和调节microRNA表达来作为靶基因的直接和间接调节剂。在DC中，Blimp-1已被鉴定为参与抗原呈递的组分之一。全基因组关联研究确定了与多种自身免疫性疾病相关的多态性，如系统性红斑狼疮、类风湿性关节炎和PRDM 1（编码Blimp-1蛋白的基因）中的炎症性肠病。在这篇综述中，我们将讨论Blimp-1在DC中的免疫调节功能，主要关注Blimp-1保护自身免疫性疾病发展所需的耐受性机制。
Previous studies have identified the immunological functions of transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) in various adaptive immune cell types such as T and B lymphocytes. More recently, it has been shown that Blimp-1 extends its functional roles to dendritic cells (DCs) and macrophages, two cell types belonging to the innate immune system. The protein acts as a direct and indirect regulator of target genes by recruiting chromatin modification factors and by regulating microRNA expression, respectively. In DCs, Blimp-1 has been identified as one of the components involved in antigen presentation. Genome-wide association studies identified polymorphisms associated with multiple autoimmune diseases such as system lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease in PRDM1, the gene encoding Blimp-1 protein. In this review, we will discuss the immune regulatory functions of Blimp-1 in DCs with a main focus on the tolerogenic mechanisms of Blimp-1 required to protect against the development of autoimmune diseases.