Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.
Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.
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大鼠的耳软骨炎。用II型胶原蛋白诱导的复发多发性炎的实验模型。
DOI：
10.1084/jem.154.2.535
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发表时间：
1981-08-01
影响因子：
15.3
通讯作者：
Townes, A S
中科院分区：
文献类型：
--
作者：
Cremer, M A;Pitcock, J A;Stuart, J M;Kang, A H;Townes, A S
用天然II型胶原免疫的远系Wistar大鼠出现类似于人类复发性中耳炎的耳部病变。与人类疾病一样，这些病变的特征在于强烈的尿道炎、IgG和C3阳性免疫荧光反应以及与天然II型胶原反应的循环IgG。此外，在软骨细胞表面附近观察到电子致密沉积物，并与IgG和C3的沉积物相对应。这些观察结果表明，体液免疫II型胶原蛋白和耳炎大鼠之间的因果关系，并支持假设比人类复发性多囊炎是一种自身免疫性疾病介导的免疫II型胶原蛋白。
Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes and corresponded with deposits of IgG and C3. These observations suggest a causal relation between humoral immunity to type II collagen and auricular chondritis in the rat and support the hypothesis than human relapsing polychondritis is an autoimmune disease mediated by immunity to type II collagen.