National estimates of the timing of sexual maturation and racial differences among US children
National estimates of the timing of sexual maturation and racial differences among US children
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DOI：
10.1542/peds.110.5.911
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发表时间：
2002-11-01
期刊：
影响因子：
8
通讯作者：
Ryan, AS
中科院分区：
文献类型：
--
作者：
Sun, SMS;Schubert, CM;Ryan, AS
Objective.为了提供临床上有意义的，规范性的参考数据，描述性成熟指标之间的美国儿童的全国样本的时间，并确定这些估计的种族/民族差异的程度为每个成熟indicator. Methods。性成熟指标的坦纳分期评估记录了4263名非西班牙裔白色，黑人和墨西哥裔美国女孩和男孩，年龄为8.00至19.00年的一部分，第三次全国健康和营养检查调查（NHANES III）在1988年和1994年之间进行。NHANES III遵循复杂的，分层的，多阶段的概率聚类设计。SUDAAN用于计算每个成熟阶段的平均年龄和标准误差以及进入成熟阶段的比例，并纳入NHANES III复杂抽样设计的抽样权重和设计效果。应用SAS 8.2软件进行概率分析，计算进入成熟期的年龄中位数及其置信限。成年阶段入组年龄的参考数据以表格和图形形式列出。非西班牙裔黑人女孩的阴毛和乳房发育的中位年龄或平均年龄比墨西哥裔美国人或非西班牙裔白色女孩更早。墨西哥裔美国人和非西班牙裔白色女孩之间几乎没有显著差异。非西班牙裔黑人男孩性成熟阶段的中位数和平均年龄也早于非西班牙裔白色和墨西哥裔美国男孩。非西班牙裔黑人女孩和男孩成熟早，但美国儿童在大约相同的年龄完成了他们的性发育。目前的性成熟时间的参考数据，建议在美国儿童的性成熟评估的解释。
Objective. To provide clinically meaningful, normative reference data that describe the timing of sexual maturity indicators among a national sample of US children and to determine the degree of racial/ethnic differences in these estimates for each maturity indicator.Methods. Tanner staging assessment of sexual maturity indicators was recorded from 4263 non-Hispanic white, black, and Mexican American girls and boys aged 8.00 to 19.00 years as part of the Third National Health and Nutrition Examination Survey (NHANES III) conducted between 1988 and 1994. NHANES III followed a complex, stratified, multistage probability cluster design. SUDAAN was used to calculate the mean age and standard error for each maturity stage and the proportion of entry into a maturity stage and to incorporate the sampling weight and design effects of the NHANES III complex sampling design. Probit analysis and median age at entry into a maturity stage and its fiducial limits were calculated using SAS 8.2.Results. Reference data for age at entry for maturity stages are presented in tabular and graphical format. Non-Hispanic black girls had an earlier sexual development for pubic hair and breast development either by median age at entry for a stage or for the mean age for a stage than Mexican American or non-Hispanic white girls. There were few to no significant differences between the Mexican American and non-Hispanic white girls. Non-Hispanic black boys also had earlier median and mean ages for sexual maturity stages than the non-Hispanic white and Mexican American boys.Conclusion. Non-Hispanic black girls and boys mature early, but US children completed their sexual development at approximately the same ages. The present reference data for the timing of sexual maturation are recommended for the interpretation of assessments of sexual maturity in US children.