Major molecular differences between mammalian sexes are involved in drug metabolism and renal function
Major molecular differences between mammalian sexes are involved in drug metabolism and renal function
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DOI：
10.1016/j.devcel.2004.05.005
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发表时间：
2004-06-01
影响因子：
11.8
通讯作者：
Snyder, M
中科院分区：
文献类型：
--
作者：
Rinn, JL;Rozowsky, JS;Snyder, M
男性和女性之间存在许多解剖学差异；这些咏叹调通过不同的荷尔蒙环境在分子水平上表现出来。尽管已经确定了成体组织中的一些分子差异，但尚未对男性和女性之间的基因表达差异进行全面的研究。我们调查了雄性和雌性下丘脑、肾脏、肝脏和生殖组织中 13,977 个小鼠基因的表达模式。不仅在生殖组织中，还在肾脏和肝脏中观察到广泛的差异基因表达。差异表达的基因涉及药物和类固醇代谢、渗透压调节或尚未解决的细胞作用。相比之下，在小鼠和人类的雄性和雌性下丘脑之间观察到的分子差异非常小。我们的结论是，成年男性和女性之间的基因表达存在持续的差异。这些分子差异对男性和女性之间的生理差异具有重要意义。
Many anatomical differences exist between males and females; these aria manifested on a molecular level by different hormonal environments. Although several molecular differences in adult tissues have been identified, a comprehensive investigation of the gene expression differences between males and females has not been performed. We surveyed the expression patterns of 13,977 mouse genes in male and female hypothalamus, kidney, liver, and reproductive tissues. Extensive differential gene expression was observed not only in the reproductive tissues, but also in the kidney and liver. The differentially expressed genes are involved in drug and steroid metabolism, osmotic regulation, or as yet unresolved cellular roles. In contrast, very few molecular differences were observed between the male and female hypothalamus in both mice and humans. We conclude that there are persistent differences in gene expression between adult males and females. These molecular differences have important implications for the physiological differences between males and females.