Effect of FASN gene on milk yield and milk composition in the Chinese Holstein dairy population
Effect of FASN gene on milk yield and milk composition in the Chinese Holstein dairy population
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DOI：
10.1111/age.12089
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发表时间：
2014-02-01
期刊：
影响因子：
2.4
通讯作者：
Sun, D. X.
中科院分区：
文献类型：
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作者：
Alim, M. A.;Wang, P.;Sun, D. X.
脂肪酸合成酶（Fatty acid synthase，FATS-N）是一种多功能蛋白，催化细胞内脂肪酸的从头合成。它在所有活动物的脂质生物合成以及一般代谢中起关键作用。我们在此研究了FIGH 7的多态性。结果发现6个单核苷酸多态性（SNPs），然后在752个中国荷斯坦奶牛基因型。结果表明，g.17924A>G为非同义突变，g.13965 C>T、g.16907 T>C和g.18663T>C为同义突变，另外两个SNP g.8948 C>T（ss 491228481）和g.14439T>C（rs 133498277）位于基因的内含子序列中。发现所有这些鉴定的SNPs与产奶量和组成性状相关（P=0.0441至0.0445）。
Fatty acid synthase (FASN) is a multifunctional protein that catalyzes de novo synthesis of fatty acids in cells. It plays a key role in the lipid biosynthesis as well as in the general metabolism of all living animals. We herein investigated polymorphisms of FASN. As a result, six single nucleotide polymorphisms (SNPs) were found and then genotyped in 752 Chinese Holstein cows. It was found that g.17924A>G was non-synonymous, g.13965 C>T, g.16907 T>C and g.18663T>C were synonymous mutations and two other two SNPs, g.8948 C>T (ss491228481) and g.14439T>C (rs133498277), were in intronic sequences of the gene. All such identified SNPs were found to be associated with milk yield and composition traits (P=0.0441 to