Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events
Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events
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DOI：
10.1089/bio.2019.0129
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发表时间：
2020-04-17
影响因子：
1.6
通讯作者：
Silander, Kaisa
中科院分区：
文献类型：
--
作者：
Eklund, Niina;Andrianarisoa, Ny Haingo;Silander, Kaisa
简介：关于生物库数据共享的最低信息（MIABIS）于2012年启动。MIABIS旨在创建一个通用的生物库术语，以促进生物库和样本收集中的数据共享。MIABIS核心术语由描述生物库、样本采集和研究的三个组成部分组成，其中以汇总形式提供了关于样本和样本供体的信息。然而，还需要在个人层面上描述样本和样本供体，以便对现有生物库样本和数据进行更详细的查询。因此，MIABIS术语现在已经扩展到描述样品和样品供体的组件，在个人水平上。材料和方法：根据BBMRI-ERIC（生物库和生物分子资源研究框架结构-欧洲研究基础设施联盟）的新MIABIS治理模型，由一个大型专家组根据特定范围和用例，并通过几个周期的审查，定义了组件。在开发这些组件中应用的指导原则包括以下条款：模型应该只考虑人类来源的样本，模型应该适用于所有类型的样本和所有样本供体，模型应该描述存储在一个给定的biobank.Results的样本的当前状态：一个最小的一组标准属性定义的样本和样本供体在这里。我们添加了一个“事件”组件来描述不直接描述样本或样本供体但与它们紧密相关的属性。为了更好地利用通用数据模型，我们建议一个程序，通过它可以促进互操作性，使用特定的MIABIS profiles.Discussion：MIABIS样本和捐助者组件扩展和新的通用数据模型补充现有的MIABIS核心2.0组件，并大大增加了潜在的可用性，这个术语更好地描述生物库样本和样本捐助者。它们还支持使用关于样本和样本供体的个体水平数据，以获得准确和详细的生物库可用性查询。
Introduction: The Minimum Information About BIobank data Sharing (MIABIS) was initiated in 2012. MIABIS aims to create a common biobank terminology to facilitate data sharing in biobanks and sample collections. The MIABIS Core terminology consists of three components describing biobanks, sample collections, and studies, in which information on samples and sample donors is provided at aggregated form. However, there is also a need to describe samples and sample donors at an individual level to allow more elaborate queries on available biobank samples and data. Therefore the MIABIS terminology has now been extended with components describing samples and sample donors at an individual level.Materials and Methods: The components were defined according to specific scope and use cases by a large group of experts, and through several cycles of reviews, according to the new MIABIS governance model of BBMRI-ERIC (Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortium). The guiding principles applied in developing these components included the following terms: model should consider only samples of human origin, model should be applicable to all types of samples and all sample donors, and model should describe the current status of samples stored in a given biobank.Results: A minimal set of standard attributes for defining samples and sample donors is presented here. We added an "event" component to describe attributes that are not directly describing samples or sample donors but are tightly related to them. To better utilize the generic data model, we suggest a procedure by which interoperability can be promoted, using specific MIABIS profiles.Discussion: The MIABIS sample and donor component extensions and the new generic data model complement the existing MIABIS Core 2.0 components, and substantially increase the potential usability of this terminology for better describing biobank samples and sample donors. They also support the use of individual level data about samples and sample donors to obtain accurate and detailed biobank availability queries.