High frequency oscillations mirror disease activity in patients with focal cortical dysplasia
High frequency oscillations mirror disease activity in patients with focal cortical dysplasia
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DOI：
10.1111/epi.12262
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发表时间：
2013-08-01
期刊：
影响因子：
5.6
通讯作者：
Jacobs, Julia
中科院分区：
文献类型：
--
作者：
Kerber, Karolin;LeVan, Pierre;Jacobs, Julia
目的分析22例难治性癫痫患者不同类型局灶性皮质发育不良高频振荡的发生情况。高频振荡是癫痫组织的生物标志物，但目前尚不清楚它们是否可以反映日益发育不良的组织变化以及癫痫疾病activity.Methods高频振荡（80- 450 Hz）视觉标记的两个独立的审查员在所有通道的颅内植入的网格，条，和深度电极的患者局灶性皮质发育不良和难治性癫痫。将病理证实的Palmini 1a和B型局灶性皮质发育不良患者的高频振荡率与2a和B型患者进行比较。关键发现2型局灶性皮质发育不良患者的癫痫发作明显多于1型（P
Purpose The study analyzes the occurrence of high frequency oscillations in different types of focal cortical dysplasia in 22 patients with refractory epilepsy. High frequency oscillations are biomarkers for epileptic tissue, but it is unknown whether they can reflect increasingly dysplastic tissue changes as well as epileptic disease activity.Methods High frequency oscillations (80-450Hz) were visually marked by two independent reviewers in all channels of intracranial implanted grid, strips, and depth electrodes in patients with focal cortical dysplasia and refractory epilepsy. Rates of high frequency oscillations in patients with pathologically confirmed focal cortical dysplasia of Palmini type 1a and b were compared with those in type 2a and b.Key Findings Patients with focal cortical dysplasia type 2 had significantly more seizures than those with type 1 (p